Cited 182 times in
Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2015-04-24T16:40:44Z | - |
dc.date.available | 2015-04-24T16:40:44Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103966 | - |
dc.description.abstract | BACKGROUND: Whether triple antiplatelet therapy is superior or similar to dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention in the era of drug-eluting stents remains unclear. METHODS AND RESULTS: A total of 4203 ST-segment elevation myocardial infarction patients who underwent primary percutaneous coronary intervention with drug-eluting stents were analyzed retrospectively in the Korean Acute Myocardial Infarction Registry (KAMIR). They received either dual (aspirin plus clopidogrel; dual group; n=2569) or triple (aspirin plus clopidogrel plus cilostazol; triple group; n=1634) antiplatelet therapy. The triple group received additional cilostazol at least for 1 month. Various major adverse cardiac events at 8 months were compared between these 2 groups. Compared with the dual group, the triple group had a similar incidence of major bleeding events but a significantly lower incidence of in-hospital mortality. Clinical outcomes at 8 months showed that the triple group had significantly lower incidences of cardiac death (adjusted odds ratio, 0.52; 95% confidence interval, 0.32 to 0.84; P=0.007), total death (adjusted odds ratio, 0.60; 95% confidence interval, 0.41 to 0.89; P=0.010), and total major adverse cardiac events (adjusted odds ratio, 0.74; 95% confidence interval, 0.58 to 0.95; P=0.019) than the dual group. Subgroup analysis showed that older (>65 years old), female, and diabetic patients got more benefits from triple antiplatelet therapy than their counterparts who received dual antiplatelet therapy. CONCLUSIONS: Triple antiplatelet therapy seems to be superior to dual antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stents. These results may provide the rationale for the use of triple antiplatelet therapy in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3207~3214 | - |
dc.relation.isPartOf | CIRCULATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary* | - |
dc.subject.MESH | Aspirin/therapeutic use | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Coronary Thrombosis/prevention & control* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/diagnosis | - |
dc.subject.MESH | Myocardial Infarction/drug therapy* | - |
dc.subject.MESH | Myocardial Infarction/mortality* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/therapeutic use* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tetrazoles/therapeutic use | - |
dc.subject.MESH | Ticlopidine/analogs & derivatives | - |
dc.subject.MESH | Ticlopidine/therapeutic use | - |
dc.title | Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Kang-Yin Chen | - |
dc.contributor.googleauthor | Seung-Woon Rha | - |
dc.contributor.googleauthor | Yong-Jian Li | - |
dc.contributor.googleauthor | Kanhaiya L. Poddar | - |
dc.contributor.googleauthor | Zhe Jin | - |
dc.contributor.googleauthor | Yoshiyasu Minami | - |
dc.contributor.googleauthor | Lin Wang | - |
dc.contributor.googleauthor | Eung Ju Kim | - |
dc.contributor.googleauthor | Chang Gyu Park | - |
dc.contributor.googleauthor | Hong Seog Seo | - |
dc.contributor.googleauthor | Dong Joo Oh | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Young Keun Ahn | - |
dc.contributor.googleauthor | Taek Jong Hong | - |
dc.contributor.googleauthor | Young Jo Kim | - |
dc.contributor.googleauthor | Seung Ho Hur | - |
dc.contributor.googleauthor | In Whan Seong | - |
dc.contributor.googleauthor | Jei Keon Chae | - |
dc.contributor.googleauthor | Myeong Chan Cho | - |
dc.contributor.googleauthor | Jang Ho Bae | - |
dc.contributor.googleauthor | Dong Hoon Choi | - |
dc.contributor.googleauthor | Yang Soo Jang | - |
dc.contributor.googleauthor | In Ho Chae | - |
dc.contributor.googleauthor | Chong Jin Kim | - |
dc.contributor.googleauthor | Jung Han Yoon | - |
dc.contributor.googleauthor | Wook Sung Chung | - |
dc.contributor.googleauthor | Ki Bae Seung | - |
dc.contributor.googleauthor | Seung Jung Park | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.108.822791 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00533 | - |
dc.identifier.eissn | 1524-4539 | - |
dc.identifier.pmid | 19528339 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.citation.volume | 119 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 3207 | - |
dc.citation.endPage | 3214 | - |
dc.identifier.bibliographicCitation | CIRCULATION, Vol.119(25) : 3207-3214, 2009 | - |
dc.identifier.rimsid | 46730 | - |
dc.type.rims | ART | - |
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