Cited 38 times in
Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1) expression.
DC Field | Value | Language |
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dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2015-04-24T16:40:34Z | - |
dc.date.available | 2015-04-24T16:40:34Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103961 | - |
dc.description.abstract | Reactive oxygen species (ROS) steady-state levels are required for entry into the S phase of the cell cycle in normal cells, as well as in tumour cells. However, the contribution of mitochondrial ROS to normal cell proliferation has not been well investigated thus far. A previous report showed that Romo1 was responsible for the high ROS levels in tumour cells. Here, we show that endogenous ROS generated by Romo1 are indispensable for cell cycle transition from G1 to S phase in normal WI-38 human lung fibroblasts. The ROS level in these cells was down-regulated by Romo1 knockdown, resulting in cell cycle arrest in the G1 phase. This arrest was associated with an increase in the level of p27(Kip1). These results demonstrate that mitochondrial ROS generated by Romo1 expression is required for normal cell proliferation and it is suggested that Romo1 plays an important role in redox signalling during normal cell proliferation | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 729~737 | - |
dc.relation.isPartOf | FREE RADICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Cycle/physiology* | - |
dc.subject.MESH | Cell Division | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p27/biosynthesis | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p27/genetics | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p27/physiology* | - |
dc.subject.MESH | Fibroblasts/metabolism* | - |
dc.subject.MESH | Gene Expression Regulation/physiology* | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Proteins/antagonists & inhibitors | - |
dc.subject.MESH | Membrane Proteins/genetics | - |
dc.subject.MESH | Membrane Proteins/physiology* | - |
dc.subject.MESH | Mitochondria/metabolism* | - |
dc.subject.MESH | Mitochondrial Proteins/antagonists & inhibitors | - |
dc.subject.MESH | Mitochondrial Proteins/genetics | - |
dc.subject.MESH | Mitochondrial Proteins/physiology* | - |
dc.subject.MESH | RNA, Small Interfering/pharmacology | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.title | Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1) expression. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | JIN SIL CHUNG | - |
dc.contributor.googleauthor | SEUNG BAEK LEE | - |
dc.contributor.googleauthor | SEON HO PARK | - |
dc.contributor.googleauthor | SUNG TAE KANG | - |
dc.contributor.googleauthor | AH RAM NA | - |
dc.contributor.googleauthor | TONG-SHIN CHANG | - |
dc.contributor.googleauthor | HYUNG JUNG KIM | - |
dc.contributor.googleauthor | YOUNG DO YOO | - |
dc.identifier.doi | 10.1080/10715760903038432 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01158 | - |
dc.relation.journalcode | J00907 | - |
dc.identifier.eissn | 1029-2470 | - |
dc.identifier.pmid | 19513905 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/10715760903038432 | - |
dc.subject.keyword | Reactive oxygen species | - |
dc.subject.keyword | Romo1 | - |
dc.subject.keyword | p27Kip1 | - |
dc.subject.keyword | Cell cycle arrest | - |
dc.subject.keyword | mitochondria | - |
dc.subject.keyword | redox signalling | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.citation.volume | 43 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 729 | - |
dc.citation.endPage | 737 | - |
dc.identifier.bibliographicCitation | FREE RADICAL RESEARCH, Vol.43(8) : 729-737, 2009 | - |
dc.identifier.rimsid | 46725 | - |
dc.type.rims | ART | - |
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