Cited 13 times in
BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia.
DC Field | Value | Language |
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dc.contributor.author | 박태성 | - |
dc.contributor.author | 송재우 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-04-24T16:39:34Z | - |
dc.date.available | 2015-04-24T16:39:34Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103929 | - |
dc.description.abstract | The role of BCR/ABL isoforms and their relationship to leukemia phenotype have been of major concern. Atypical BCR/ABL mRNA transcripts lacking exon a2 have been reported in 12 cases of acute lymphoblastic leukemia (ALL) to date; among them, a b3a3 type transcript has been reported only once in the childhood ALL. Reported here is the case of a patient with Philadelphia-positive (Ph(+)) ALL expressing a b3a3 type transcript, a rare type of BCR/ABL mRNA lacking ABL exon a2 sequences. Bone marrow showed a hypercellular marrow with leukemic blasts positive for CD10, CD19, CD79a, and cytoplasmic mu, which is consistent with pre-B ALL. The G-banding and fluorescence in situ hybridization analyses indicated Ph(+). After the patient was diagnosed with ALL-L2, induction chemotherapy was performed and imatinib mesylate was thereafter given as the maintenance therapy. Sequencing analysis showed deletion of ABL a2 in the polymerase chain reaction product, which corresponded to a b3a3 fusion transcript. To our knowledge, this is the second report of an aberrant BCR/ABL product lacking ABL exon a2 in childhood ALL | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 132~137 | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Chromosomes, Human, Pair 22 | - |
dc.subject.MESH | Chromosomes, Human, Pair 9 | - |
dc.subject.MESH | Cytogenetic Analysis | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Exons/genetics | - |
dc.subject.MESH | Fusion Proteins, bcr-abl/genetics* | - |
dc.subject.MESH | Fusion Proteins, bcr-abl/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics* | - |
dc.subject.MESH | Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism | - |
dc.subject.MESH | Protein Isoforms/genetics | - |
dc.subject.MESH | Protein Isoforms/metabolism | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Translocation, Genetic | - |
dc.title | BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.contributor.googleauthor | Sue Jung Kim | - |
dc.contributor.googleauthor | Hyeon-Ji Lee | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2008.11.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01725 | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 19215796 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460808006687 | - |
dc.contributor.alternativeName | Park, Tae Sung | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Park, Tae Sung | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.citation.volume | 189 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 137 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.189(2) : 132-137, 2009 | - |
dc.identifier.rimsid | 37892 | - |
dc.type.rims | ART | - |
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