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J.Leonard Goldner Award 2008. Effect of extracorporeal shock wave therapy on cultured tenocytes

DC FieldValueLanguage
dc.contributor.author이진우-
dc.date.accessioned2015-04-24T16:39:14Z-
dc.date.available2015-04-24T16:39:14Z-
dc.date.issued2009-
dc.identifier.issn1071-1007-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103919-
dc.description.abstractBACKGROUND: Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation. MATERIALS AND METHODS: Diseased Achilles tendon tissue and healthy flexor hallucis longus tissue were used. Shock wave treatment was applied to cultured cells at 0.17 mJ/mm(2)energy 250, 500, 1000, and 2000 times. RESULTS: A dose-dependent decrease in cell viability was noted in cells receiving 1000 and 2000 shocks (86.0 +/- 5.6%, p = 0.01 and 72.4 +/- 8.9%, p = 0.001) as compared with the normal control. Cell count in the 500-shock group increased by 23.4% as compared with the control (p = 0.05). The concentration of MMP 1, 2, and 13 was higher in diseased tenocytes as compared with normal cells (p = 0.04, all comparisons). IL-6 levels were higher in the diseased tenocytes as compared with normal tenocytes (44.10 +/- 16.72 versus 0.21 +/- 0.55 ng/ml, (p < 0.05). IL-1 levels in normal cells increased (2.24 +/- 5.02 ng/ml to 9.31 +/- 6.85 ng/ml) after shock wave treatment (p = 0.04). In diseased tenocytes, levels of MMP-1 (1.12 +/- 0.23 to 0.75 +/- 0.24 ng/ml; p = 0.04) and MMP-13 (1.43 +/- 0.11 to 0.80 +/- 0.15 ng/ml; p = 0.04) were significantly decreased after shock wave treatment. The IL-6 level in diseased tenocytes was decreased (44.10 +/- 16.72 to 14.66 +/- 9.49 ng/ml) after shock wave treatment (p = 0.04). CONCLUSION: Higher levels of MMPs and ILs were found in human tendinopathy-affected tenocytes as compared with normal cells. ESWT decreased the expression of several MMPs and ILs. CLINICAL RELEVANCE: This mechanism may play an important role in shock wave treatment of tendinopathy clinically-
dc.description.statementOfResponsibilityopen-
dc.format.extent93~98-
dc.relation.isPartOfFOOT & ANKLE INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAwards and Prizes*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHHigh-Energy Shock Waves/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHMatrix Metalloproteinases/metabolism-
dc.subject.MESHTendinopathy/metabolism-
dc.subject.MESHTendons/cytology*-
dc.subject.MESHTendons/metabolism-
dc.subject.MESHTendons/radiation effects*-
dc.titleJ.Leonard Goldner Award 2008. Effect of extracorporeal shock wave therapy on cultured tenocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorSeung Hwan Han-
dc.contributor.googleauthorJin Woo Lee-
dc.contributor.googleauthorGregory P. Guyton-
dc.contributor.googleauthorBrent G. Parks-
dc.contributor.googleauthorJean-Paul Courneya-
dc.contributor.googleauthorLew C. Schon-
dc.identifier.doi10.3113/FAI.2009.0093-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03230-
dc.relation.journalcodeJ00902-
dc.identifier.eissn1944-7876-
dc.identifier.pmid19254500-
dc.identifier.urlhttp://fai.sagepub.com/content/30/2/93.abstract-
dc.subject.keywordExtracorporeal Shock Wave-
dc.subject.keywordTendon-
dc.subject.keywordCells-
dc.subject.keywordESWT-
dc.contributor.alternativeNameLee, Jin Woo-
dc.contributor.affiliatedAuthorLee, Jin Woo-
dc.citation.volume30-
dc.citation.number2-
dc.citation.startPage93-
dc.citation.endPage98-
dc.identifier.bibliographicCitationFOOT & ANKLE INTERNATIONAL, Vol.30(2) : 93-98, 2009-
dc.identifier.rimsid37885-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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