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Cited 29 times in

The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription

DC FieldValueLanguage
dc.contributor.author강희범-
dc.contributor.author김한천-
dc.contributor.author유정윤-
dc.contributor.author윤호근-
dc.contributor.author이유현-
dc.contributor.author최경철-
dc.date.accessioned2015-04-24T16:38:56Z-
dc.date.available2015-04-24T16:38:56Z-
dc.date.issued2009-
dc.identifier.issn0014-5793-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103910-
dc.description.abstractIn this study, we discovered that NSD2 specifically interacts with the DNA-binding domain of androgen receptor (AR) via its HMG domain, and the nuclear translocation of both NSD2 and AR is enhanced in the presence of ligand. Furthermore, we also demonstrated that the over expression of NSD2, but not of NSD2 (DeltaSET) HMT-activity defective mutant, enhanced the mRNA level of PSA in a dose-dependent manner. A chromatin immunoprecipitation assay showed that NSD2 protein is recruited to the enhancer region of the PSA gene by AR in an agonist-enhanced manner. Taken together, these results uncover a potential role for NSD2 in AR-mediated transcription, implicating NSD2 in prostate carcinogenesis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1880~1886-
dc.relation.isPartOfFEBS LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActive Transport, Cell Nucleus-
dc.subject.MESHBase Sequence-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHChromatin Immunoprecipitation-
dc.subject.MESHDNA Primers/genetics-
dc.subject.MESHEnhancer Elements, Genetic-
dc.subject.MESHHistone-Lysine N-Methyltransferase/chemistry-
dc.subject.MESHHistone-Lysine N-Methyltransferase/genetics-
dc.subject.MESHHistone-Lysine N-Methyltransferase/metabolism*-
dc.subject.MESHHistones/metabolism-
dc.subject.MESHHomeodomain Proteins/genetics-
dc.subject.MESHHomeodomain Proteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLigands-
dc.subject.MESHMale-
dc.subject.MESHProstate-Specific Antigen/genetics-
dc.subject.MESHProstate-Specific Antigen/metabolism-
dc.subject.MESHProstatic Neoplasms/etiology-
dc.subject.MESHProstatic Neoplasms/genetics-
dc.subject.MESHProstatic Neoplasms/metabolism-
dc.subject.MESHProtein Interaction Domains and Motifs-
dc.subject.MESHReceptors, Androgen/chemistry-
dc.subject.MESHReceptors, Androgen/genetics-
dc.subject.MESHReceptors, Androgen/metabolism*-
dc.subject.MESHRecombinant Proteins/chemistry-
dc.subject.MESHRecombinant Proteins/genetics-
dc.subject.MESHRecombinant Proteins/metabolism-
dc.subject.MESHRepressor Proteins/chemistry-
dc.subject.MESHRepressor Proteins/genetics-
dc.subject.MESHRepressor Proteins/metabolism*-
dc.subject.MESHTranscription Factors/genetics-
dc.subject.MESHTranscription Factors/metabolism-
dc.subject.MESHTranscriptional Activation-
dc.titleThe histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorHee-Bum Kang-
dc.contributor.googleauthorYoungsok Choi-
dc.contributor.googleauthorJae Myun Lee-
dc.contributor.googleauthorKyung-Chul Choi-
dc.contributor.googleauthorHan-Cheon Kim-
dc.contributor.googleauthorJung-Yoon Yoo-
dc.contributor.googleauthorYoo-Hyun Lee-
dc.contributor.googleauthorHo-Geun Yoon-
dc.identifier.doi10.1016/j.febslet.2009.05.038-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00103-
dc.contributor.localIdA01103-
dc.contributor.localIdA02625-
dc.contributor.localIdA03017-
dc.contributor.localIdA04035-
dc.contributor.localIdA02502-
dc.relation.journalcodeJ00890-
dc.identifier.eissn1873-3468-
dc.identifier.pmid19481544-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S001457930900413X-
dc.subject.keywordNuclear SET domain-containing 2-
dc.subject.keywordAndrogen receptor-
dc.subject.keywordHistone methyltransferase-
dc.subject.keywordProstate cancer-
dc.subject.keywordTranscription-
dc.contributor.alternativeNameKang, Hee Bum-
dc.contributor.alternativeNameKim, Han Cheon-
dc.contributor.alternativeNameYoo, Jung Yoon-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameLee, Yoo Hyun-
dc.contributor.alternativeNameChoi, Kyung Chul-
dc.contributor.affiliatedAuthorKang, Hee Bum-
dc.contributor.affiliatedAuthorKim, Han Cheon-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorLee, Yoo Hyun-
dc.contributor.affiliatedAuthorChoi, Kyung Chul-
dc.contributor.affiliatedAuthorYoo, Jung Yoon-
dc.contributor.affiliatedAuthor유정윤-
dc.citation.volume583-
dc.citation.number12-
dc.citation.startPage1880-
dc.citation.endPage1886-
dc.identifier.bibliographicCitationFEBS LETTERS, Vol.583(12) : 1880-1886, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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