Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

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Authors: Min Ji An ; Jae Hee Cheon ; Seung Won Kim ; Eun Soo Kim ; Tae Il Kim ; Won Ho Kim

MeSH: Animals ; Antineoplastic Agents, Phytogenic/pharmacology* ; Apoptosis/drug effects* ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Baculoviral IAP Repeat-Containing 3 Protein ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Proliferation/drug effects* ; Colorectal Neoplasms/drug therapy* ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Enzyme Activation ; HT29 Cells ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Mice ; Mice, Nude ; Phosphorylation ; Pregnenediones/pharmacology* ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-jun/metabolism ; Time Factors ; Ubiquitin-Protein Ligases ; Xenograft Model Antitumor Assays ; fas Receptor/metabolism

Abstract: The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer

Full Text: http://www.sciencedirect.com/science/article/pii/S0304383509000603

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers

Yonsei Authors: Kim, Seung Won(김승원) https://orcid.org/0000-0002-1692-1192
Kim, Won Ho(김원호) https://orcid.org/0000-0002-5682-9972
Kim, Eun Soo(김은수)
Kim, Tae Il(김태일) https://orcid.org/0000-0003-4807-890X
Cheon, Jae Hee(천재희) https://orcid.org/0000-0002-2282-8904

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YUHSpace: Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts