Cited 46 times in
Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine Parkinson's disease model.
DC Field | Value | Language |
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dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2015-04-24T16:38:17Z | - |
dc.date.available | 2015-04-24T16:38:17Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0953-816X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103890 | - |
dc.description.abstract | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that has the potential for clinical application. The biological effects of GM-CSF have been well characterized, and include stimulation of bone marrow hematopoietic stem cell proliferation and inhibition of apoptosis of hematopoietic cells. In contrast, the therapeutic effects of GM-CSF on the central nervous system in acute injury such as stroke and spinal cord injury have been reported only recently. To better understand the protective effect of GM-CSF on dopaminergic neurons in Parkinson's disease (PD), we investigated the effect of GM-CSF on the survival of dopamine neurons and changes in locomotor behavior in a murine PD model. We investigated the neuroprotective effects of GM-CSF in 1-methyl-4-phenylpyridinium (MPP+)-treated PC12 cells as well as in embryonic mouse primary mesencephalic neurons (PMNs) in vitro. To investigate the role of GM-CSF in vivo, we prepared a mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) PD model, and examined the effects of GM-CSF on dopaminergic neuron survival in the substantia nigra and on locomotor behavior. Treatment with GM-CSF significantly reduced MPP+-induced dopaminergic cell death in PC12 cells and PMNs in vitro. GM-CSF modulated the expression of apoptosis-related proteins, Bcl-2 and Bax, in vitro. Furthermore, administration of GM-CSF (50 microg/kg body weight/day) in vivo for 7 days protected dopaminergic neurons in the substantia nigra and improved locomotor behavior in a mouse MPTP model of PD | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods | - |
dc.subject.MESH | Corpus Striatum/cytology | - |
dc.subject.MESH | Corpus Striatum/drug effects | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dopamine/metabolism* | - |
dc.subject.MESH | Embryo, Mammalian | - |
dc.subject.MESH | Exploratory Behavior/drug effects | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Granulocyte-Macrophage Colony-Stimulating Factor/metabolism | - |
dc.subject.MESH | Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology | - |
dc.subject.MESH | Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use* | - |
dc.subject.MESH | Locomotion/drug effects | - |
dc.subject.MESH | Membrane Potentials/drug effects | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neurons/drug effects* | - |
dc.subject.MESH | Parkinson Disease, Secondary/chemically induced* | - |
dc.subject.MESH | Parkinson Disease, Secondary/physiopathology | - |
dc.subject.MESH | Parkinson Disease, Secondary/prevention & control* | - |
dc.subject.MESH | Patch-Clamp Techniques/methods | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Receptor, Macrophage Colony-Stimulating Factor/metabolism | - |
dc.subject.MESH | Substantia Nigra/pathology | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tyrosine 3-Monooxygenase/metabolism | - |
dc.subject.MESH | bcl-2-Associated X Protein/genetics | - |
dc.subject.MESH | bcl-2-Associated X Protein/metabolism | - |
dc.title | Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine Parkinson's disease model. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Na K. Kim | - |
dc.contributor.googleauthor | Byung H. Choi | - |
dc.contributor.googleauthor | Xian Huang | - |
dc.contributor.googleauthor | Brian J. Snyder | - |
dc.contributor.googleauthor | Shefqat Bukhari | - |
dc.contributor.googleauthor | Tae-Ho Kong | - |
dc.contributor.googleauthor | Hyeonseon Park | - |
dc.contributor.googleauthor | Hyung C. Park | - |
dc.contributor.googleauthor | So R. Park | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.identifier.doi | 10.1111/j.1460-9568.2009.06653.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01739 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J00831 | - |
dc.identifier.eissn | 1460-9568 | - |
dc.identifier.pmid | 19245369 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2009.06653.x/abstract | - |
dc.subject.keyword | dopamine neuron | - |
dc.subject.keyword | granulocyte–macrophage colony‐stimulating factor (GM‐CSF) | - |
dc.subject.keyword | neuroprotection | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | Ha, Yoon | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 891 | - |
dc.citation.endPage | 900 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROSCIENCE, Vol.29(5) : 891-900, 2009 | - |
dc.identifier.rimsid | 37860 | - |
dc.type.rims | ART | - |
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