Cited 44 times in
Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 윤영준 | - |
dc.contributor.author | 이중민 | - |
dc.date.accessioned | 2015-04-24T16:38:06Z | - |
dc.date.available | 2015-04-24T16:38:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103884 | - |
dc.description.abstract | Recently, hepatitis B virus (HBV) genotypes and mutations have been reported to be related to hepatocellular carcinoma (HCC). This cross-sectional case-control study examined the relationship between HCC and mutations in the enhancer II/core promoter and precore regions of HBV by comparing 135 Korean HCC patients infected with HBV genotype C2 (HBV/C2; HCC group) with 135 age-, sex-, and hepatitis B e antigen (HBeAg) status-matched patients without HCC (non- HCC group). Age and sex were also matched between HBeAg-positive and -negative patients. The prevalence of T1653, A1689, V1753, T1762/A1764, T1846, A1850, C1858, and A1896 mutations was evaluated in this population. The prevalence of the T1653 mutation in the box alpha region, the T1689 [corrected] mutation in between the box alpha and beta regions, and the T1762/A1764 mutations in the basal core promoter region was significantly higher in the HCC group compared to the non-HCC group (8.9% vs. 2.2%, P = 0.017; 19.3% vs. 4.4%, P < 0.001; and 60.7% vs. 22.2%; P < 0.001). Among HBeAg-negative patients, the frequency of the T1653 mutation was higher in the HCC group. Regardless of HBeAg status, the prevalence of the T1689, [corrected] and T1762/A1764 mutations was higher in the HCC group than in the non-HCC group. However, no association was observed between mutations in the precore region and HCC. Upon multivariate analysis, the presence of the T1653, T1689, [corrected] and T1762/A1764 mutations was an independent predictive factor for HCC. The addition of the T1653 or T1689 [corrected] mutation to T1762/A1764 increased the risk of HCC. In conclusion, the T1653, T1689, [corrected] and/or T1762/A1764 mutations were associated with the development of HCC in Korean patients infected with HBV/C2. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1002~1008 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Carcinoma, Hepatocellular/virology* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | DNA, Viral/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B Core Antigens/genetics* | - |
dc.subject.MESH | Hepatitis B virus/genetics* | - |
dc.subject.MESH | Hepatitis B virus/isolation & purification | - |
dc.subject.MESH | Hepatitis B, Chronic/complications* | - |
dc.subject.MESH | Hepatitis B, Chronic/virology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Point Mutation* | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Trans-Activators/genetics* | - |
dc.subject.MESH | Viral Regulatory and Accessory Proteins/genetics* | - |
dc.title | Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Hye Young Chang | - |
dc.contributor.googleauthor | Jung Min Lee | - |
dc.contributor.googleauthor | Oidov Baatarkhuu | - |
dc.contributor.googleauthor | Young Joon Yoon | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.identifier.doi | 10.1002/jmv.21501 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02582 | - |
dc.contributor.localId | A03184 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J01587 | - |
dc.identifier.eissn | 1096-9071 | - |
dc.identifier.pmid | 19382267 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jmv.21501/abstract | - |
dc.subject.keyword | hepatitis B virus | - |
dc.subject.keyword | hepatitis B virus X protein | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | mutation | - |
dc.subject.keyword | oncogenic viruses | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Yoon, Young Joon | - |
dc.contributor.alternativeName | Lee, Jung Min | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Yoon, Young Joon | - |
dc.contributor.affiliatedAuthor | Lee, Jung Min | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 81 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1002 | - |
dc.citation.endPage | 1008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, Vol.81(6) : 1002-1008, 2009 | - |
dc.identifier.rimsid | 37857 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.