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The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection

DC FieldValueLanguage
dc.contributor.author김경식-
dc.contributor.author박승우-
dc.contributor.author이우정-
dc.contributor.author최새별-
dc.contributor.author최진섭-
dc.date.accessioned2015-04-24T16:35:26Z-
dc.date.available2015-04-24T16:35:26Z-
dc.date.issued2009-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103800-
dc.description.abstractBACKGROUND AND OBJECTIVES: The objective of this study was to analyze the survival outcome and the clinicopathological factors that influence survival and recurrence of middle and distal bile duct cancer after surgical resection. METHODS: From January 2000 to June 2007, 125 patients underwent surgical resection for middle and distal bile duct cancer. The clinicopathological characteristics and survival outcomes were reviewed retrospectively. RESULTS: Of the 125 patients, 31 patients underwent segmental resection of the bile duct, and 94 patients underwent pancreaticoduodenectomy (PD). Overall survival rates were 85.8% at 1 year and 38.3% at 5 years. Lymph node metastasis, noncurative resection, poorly differentiated tumor, and preoperative bilirubin level greater than 5.0 mg/dl were significant independent predictors of poor prognosis by multivariate analysis. The number of metastatic lymph nodes did not significantly affect survival. Recurrence occurred in 72 patients (61.0%). Disease-free survival rates were 74.1% at 1 year and 42.0% at 3 years. Lymph node and distant metastases and poorly differentiated tumors were found to be significant independent predictors of recurrence by multivariate analysis. CONCLUSIONS: R0 resection confers a survival benefit, thus the surgeon should make an effort to achieve R0 resection. The presence of lymph node metastasis was a significant prognostic factor.-
dc.description.statementOfResponsibilityopen-
dc.format.extent335~342-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHvAged-
dc.subject.MESHBile Duct Neoplasms/blood-
dc.subject.MESHBile Duct Neoplasms/mortality-
dc.subject.MESHBile Duct Neoplasms/pathology*-
dc.subject.MESHBile Duct Neoplasms/surgery*-
dc.subject.MESHBilirubin/blood*-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHDuodenal Neoplasms/secondary-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPancreatic Neoplasms/secondary-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHSurvival Analysis-
dc.titleThe survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSAE BYEOL CHOI-
dc.contributor.googleauthorSEUNG WOO PARK-
dc.contributor.googleauthorKYUNG SIK KIM-
dc.contributor.googleauthorJIN SUB CHOI-
dc.contributor.googleauthorWOO JUNG LEE-
dc.identifier.doi10.1002/jso.21238-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA01551-
dc.contributor.localIdA04069-
dc.contributor.localIdA04199-
dc.contributor.localIdA02993-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid19226533-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.21238/abstract-
dc.subject.keywordbile duct cancer-
dc.subject.keywordlymph node metastasis-
dc.subject.keywordR0 resection-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameChoi, Sae Byeol-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorChoi, Sae Byeol-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.citation.volume99-
dc.citation.number6-
dc.citation.startPage335-
dc.citation.endPage342-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.99(6) : 335-342, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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