Cited 40 times in

The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation

DC Field Value Language
dc.contributor.author박성하-
dc.contributor.author최종락-
dc.contributor.author심원흠-
dc.contributor.author하종원-
dc.contributor.author심지영-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author고영국-
dc.contributor.author조승연-
dc.contributor.author김중선-
dc.contributor.author최동훈-
dc.date.accessioned2015-04-24T16:35:13Z-
dc.date.available2015-04-24T16:35:13Z-
dc.date.issued2009-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103793-
dc.description.abstractBACKGROUND: Triple antiplatelet therapy may have a beneficial effect on prevention of thrombotic complication in patients undergoing coronary stenting. We investigated the prevalence of aspirin and clopidogrel resistance in patients treated with dual and triple antiplatelet regimen after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). METHODS: A total of 400 consecutive patients underwent successful PCI with DES were randomly assigned to therapy with dual antiplatelet regimens (aspirin plus clopidogrel, Group I, n = 200) and triple antiplatelet regimens (aspirin plus clopidogrel plus cilostazol, Group II, n = 200) At two weeks after PCI, aspirin and clopidogrel resistance were assayed in 379 patients (Group I, n = 186; Group II, n = 193) by using the VerifyNow System. RESULTS: In Group I, 21 (11.3%) patients had aspirin resistance and 74 (40.0%) had clopidogrel resistance. In Group II, 19 (9.8%) were resistant to aspirin and 38 (19.7%) to clopidogrel. The aspirin reaction unit (ARU) was not significantly different between groups (448+/-67 vs. 439+/-64, P = 0.200), but the percent inhibition of clopidogrel was higher in Group II (41.4+/-24.3%,) comparing with that of Group I (26.5+/-18.7%, P < 0.001). CONCLUSION: With triple antiplatelet therapy, the prevalence of clopidogrel resistance can be attenuated in patients undergoing PCI with DES-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCardiovascular Surgical Procedures/adverse effects-
dc.subject.MESHCardiovascular Surgical Procedures/instrumentation*-
dc.subject.MESHDrug Resistance/drug effects-
dc.subject.MESHDrug Resistance/physiology*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHDrug-Eluting Stents/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlatelet Aggregation Inhibitors/administration & dosage*-
dc.subject.MESHPostoperative Complications/drug therapy-
dc.subject.MESHPostoperative Complications/etiology-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHThrombosis/drug therapy-
dc.subject.MESHThrombosis/etiology-
dc.subject.MESHThrombosis/prevention & control-
dc.subject.MESHTiclopidine/administration & dosage-
dc.subject.MESHTiclopidine/analogs & derivatives*-
dc.titleThe clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorSe-Jung Yoon-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorWon-Heum Shim-
dc.contributor.googleauthorSeung-Yun Cho-
dc.identifier.doi10.1016/j.ijcard.2008.02.016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01512-
dc.contributor.localIdA04182-
dc.contributor.localIdA02202-
dc.contributor.localIdA04257-
dc.contributor.localIdA02213-
dc.contributor.localIdA02569-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA00127-
dc.contributor.localIdA03844-
dc.contributor.localIdA00961-
dc.contributor.localIdA04053-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid18579227-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527308004488-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.alternativeNameShim, Won Heum-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameCho, Seung Yun-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.contributor.affiliatedAuthorShim, Won Heum-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorCho, Seung Yun-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.citation.volume134-
dc.citation.number3-
dc.citation.startPage351-
dc.citation.endPage355-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.134(3) : 351-355, 2009-
dc.identifier.rimsid36695-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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