Cited 3 times in
Copy number changes can be a predictor for hemoglobin reduction after S-1 monotherapy in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 임종근 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.date.accessioned | 2015-04-24T16:34:56Z | - |
dc.date.available | 2015-04-24T16:34:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103784 | - |
dc.description.abstract | Anemia is a unique side effect in Korean gastric cancer patients after S-1 monotherapy. We studied gastric cancer patients from a phase II trial of S-1 monotherapy with a 2-week treatment and 1-week rest schedule. Patients from a phase II trial of S-1 monotherapy with a 4-week treatment and 2-week rest were used as a reference group. The patients were categorized into two groups based on the degree of hemoglobin reduction per cycle of S-1: the mild reduction group (MRG DeltaHb/cycle < or =1.0) or severe reduction group (SRG DeltaHb/cycle >1.0). DeltaHb/cycle was calculated from maximum reduction of hemoglobin per one cycle of the treatment. Microarray-CGH was performed using a 17K cDNA microarray containing 15,723 unique genes. We selected genes with copy number variation defined as amplification (log2R/G >0.68) or deletion (log2R/G <-0.68), and a genetic aberration frequency difference of > or =30% between the MRG and the SRG. There were no differences in clinical factors, S-1 treatment-related factors (dose, dose intensity), toxicity, S-1 metabolism-related gene copy numbers (CYP2A6, DPD), or progression-free survival between the MRG and the SRG. Three genes were selected from microarray-CGH and logistic regression model: logit LN(Z) = (1.321) + (1.038 x PTX1) + (0.211 x MYO5A) + (0.516 x ZNF664). In the SRG, all 3 genes showed a trend of higher copy numbers than the MRG. There were no common anemia-related genes identified from different chemotherapy schedule of S-1 monotherapy. The logistics obtained from 3 genes predicted the hemoglobin reduction with an accuracy of 78%. The AUC was 0.744 for the final regression model. The combined copy number changes of the 3 genes can be developed into a biomarker in predicting S-1 treatment-related anemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 787~796 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anemia/blood | - |
dc.subject.MESH | Anemia/chemically induced* | - |
dc.subject.MESH | Anemia/genetics | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/adverse effects* | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/therapeutic use | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Hemoglobins/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxonic Acid/adverse effects* | - |
dc.subject.MESH | Oxonic Acid/therapeutic use | - |
dc.subject.MESH | Stomach Neoplasms/blood* | - |
dc.subject.MESH | Stomach Neoplasms/drug therapy* | - |
dc.subject.MESH | Stomach Neoplasms/genetics | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Tegafur/adverse effects* | - |
dc.subject.MESH | Tegafur/therapeutic use | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Copy number changes can be a predictor for hemoglobin reduction after S-1 monotherapy in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | HEI CHEUL JEUNG | - |
dc.contributor.googleauthor | SUN YOUNG RHA | - |
dc.contributor.googleauthor | CHAN HEE PARK | - |
dc.contributor.googleauthor | CHONG-KUN IM | - |
dc.contributor.googleauthor | SANG JOON SHIN | - |
dc.contributor.googleauthor | JOONG BAE AHN | - |
dc.contributor.googleauthor | SUNG HOON NOH | - |
dc.contributor.googleauthor | JAE KYUNG ROH | - |
dc.contributor.googleauthor | HYUN CHEOL CHUNG | - |
dc.identifier.doi | 10.3892/ijo_00000204 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03402 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01141 | - |
dc.identifier.eissn | 1791-2423 | - |
dc.identifier.pmid | 19212683 | - |
dc.identifier.url | http://www.spandidos-publications.com/ijo/34/3/787?text=abstract | - |
dc.contributor.alternativeName | Im, Chong Kun | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Im, Chong Kun | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 787 | - |
dc.citation.endPage | 796 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.34(3) : 787-796, 2009 | - |
dc.identifier.rimsid | 36692 | - |
dc.type.rims | ART | - |
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