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Induction of Apoptosis in Human Oral Epidermoid Carcinoma Cell by The Essential Oil of Artemisia Scoparia WALDST. et KITAMURA
DC Field | Value | Language |
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dc.contributor.author | 차인호 | - |
dc.contributor.author | 차정단 | - |
dc.contributor.author | 이명섭 | - |
dc.contributor.author | 이생금 | - |
dc.date.accessioned | 2015-04-24T16:34:49Z | - |
dc.date.available | 2015-04-24T16:34:49Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1225-1577 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103780 | - |
dc.description.abstract | Artemisia scoparia (A. scoparia), perennial herb is indigenous to Korea and has been traditionally used in liver damage. We investigated the effect of the essential oil obtained from A. scoparia on apoptosis of KB cells. Cytotoxicity and cellular DNA content were analyzed by MTT assay and flow cytometry, agarose gel electrophoresis, and Hoechst 33258 staining. The caspase-3 and poly (ADP-ribose) polymerase (PARP) proteins were estimated by Western blotting method. We found that the essential oil induced the apoptosis of the KB cells by concentrations of 0.4 to 0.2 mg/ml which was verified by DNA fragmentation, apoptotic bodies, and the sub-G0/G1 ratio. The essential oil also transient caspase-9 and caspase-3 activity and cleavage of PARP in KB cells for 24 h. The essential oil-induced apoptotic cell death was accompanied by up-regulation of Bax and down-regulation of Bcl-2. In conclusion, we demonstrated that the essential oil of A. scoparia induces apoptosis in KB cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 75~82 | - |
dc.language | Korean | - |
dc.publisher | 대한구강악안면병리학회 | - |
dc.relation.isPartOf | Korean Journal of Oral and Maxillofacial Pathology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Induction of Apoptosis in Human Oral Epidermoid Carcinoma Cell by The Essential Oil of Artemisia Scoparia WALDST. et KITAMURA | - |
dc.title.alternative | 비쑥의 휘발성물질에 의한 KB 세포의 세포사멸 유도 | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Oral Cancer Research Institute (구강종양연구소) | - |
dc.contributor.googleauthor | Jeong-Dan Cha | - |
dc.contributor.googleauthor | ShengJin, Li | - |
dc.contributor.googleauthor | Myeong-Seop Lee | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04005 | - |
dc.contributor.localId | A02750 | - |
dc.contributor.localId | A02846 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J02084 | - |
dc.subject.keyword | Artemisia scoparia | - |
dc.subject.keyword | Essential oil | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Cell cycle | - |
dc.subject.keyword | Caspase-3 | - |
dc.subject.keyword | PARP | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.alternativeName | Cha, Jeong Dan | - |
dc.contributor.alternativeName | Lee, Myeong Seop | - |
dc.contributor.alternativeName | Li, Sheng Jin | - |
dc.contributor.affiliatedAuthor | Cha, Jeong Dan | - |
dc.contributor.affiliatedAuthor | Lee, Myeong Seop | - |
dc.contributor.affiliatedAuthor | Li, Sheng Jin | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 82 | - |
dc.identifier.bibliographicCitation | Korean Journal of Oral and Maxillofacial Pathology, Vol.33(1) : 75-82, 2009 | - |
dc.identifier.rimsid | 36689 | - |
dc.type.rims | ART | - |
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