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구강암 세포주의 이소위 누드마우스 종양 모델

Other Titles
 AN ATOPIC NUDE MOUSE MODEL OF ORAL CANCER CELL LINE 
Authors
 김종현  ;  황영선  ;  김현실  ;  남웅  ;  차인호 
Citation
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.35(2) : 74-82, 2009 
Journal Title
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지) 
ISSN
 1225-1585 
Issue Date
2009
Keywords
Oral cancer ; Tongue cancer ; Squamous cell carcinoma ; Atopic nude mouse model ; Cell line
Abstract
In order to make successful oral cancer treatment, we need to understand about tumor biology and effective chemotherapeutic agents. To achieve these studies, it is necessary to develope a proper in-vivo model. Therefore the author will make try to develop more improved animal model of more applicable in various method of cancer study. In this study, the author induced in-vivo tumorigenesis in nude mice by YD-10Bmod cell line used by YD-10B cell line originated from oral tongue squamous cell carcinoma and observed tumor formations and invasiveness of surrounding tissue, and found some results as follows : 1. The experimental group (YD-10Bmod, subcutaneous injection) produced tumors 13 out of 15 mice, while the control group produced none of 5 mice. 2. The inoculation of 1×10⁶cells/mouse produced tumors 3 out of 5 mice and inoculation of 1×10⁷cells/mouse, 2×10⁷cells/mouse produced tumors in every 5 mice. 3. In the histopathologic studies, the inoculation of 1×106cells/mouse group showed the characteristic features of well-differentiated squamous cell carcinoma and demarcated expansile growth, while the inoculation of 1×10⁷cells/mouse, 2×10⁷cells/mouse group showed the expansile growth with partial central necrosis and invasive growth to surrounding fat & connective tissue. These findings suggest that atopic xenograft of YD-10Bmod cell line in nude mice has a improved productivity of tumors, produced tumors showed the characteristics feature of human tumor and invasive growth to surrounding tissue in histopathologic appearance. These atopic nude mouse model of tongue carcinoma might assist in studying oral cancer biology and effective choice of chemotherapeutic agents
Files in This Item:
T200901047.pdf Download
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Hwang, Young Sun(황영선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103775
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