Cited 59 times in
Determinants of exercise-induced pulmonary hypertension in patients with normal left ventricular ejection fraction.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박성하 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 최의영 | - |
dc.contributor.author | 하종원 | - |
dc.date.accessioned | 2015-04-24T16:34:23Z | - |
dc.date.available | 2015-04-24T16:34:23Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1355-6037 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103766 | - |
dc.description.abstract | BACKGROUND: Pulmonary hypertension (PH) can occur during exercise and has an adverse effect on functional status, exercise tolerance and prognosis. However, the role of cardiac function abnormalities on exercise-induced PH in patients with normal left ventricular ejection fraction (LVEF) is unclear. OBJECTIVE: To analyse exercise-induced PH determinants in patients with normal LVEF. METHODS AND RESULTS: 396 subjects (160 male, mean age 55 (SD 13)) referred for exercise echocardiography underwent a graded, symptom-limited, supine bicycle exercise with two-dimensional and Doppler echocardiography. Tricuspid regurgitation (TR) velocity was measured at rest and during exercise. Pulmonary artery systolic pressure (PASP) was estimated from TR velocity by adding a right atrial pressure of 10 mm Hg. Patients were classified according to exercise induced PH, defined as present if PASP >50 mm Hg at 50 W of exercise. 135 patients (34%) had PASP >50 mm Hg during exercise. Patients with exercise-induced PH were older, more commonly female and had shorter exercise duration; however, LVEF was significantly higher. The systolic blood pressure at rest and during exercise was significantly higher in patients with exercise-induced PH (rest, 125 (18) vs 132 (18) mm Hg, p = 0.0003; 25 W, 146 (21) vs 157 (21) mm Hg, p<0.0001; 50 W, 157 (24) vs 170 (22) mm Hg, p<0.0001; 75 W, 168 (23) vs 183 (22) mm Hg, p<0.0001). Despite similar resting oxygen saturation, exercise oxygen saturation was significantly lower in subjects with exercise-induced PH than in those without. Numerous echocardiographic variables were significantly different between groups. In multivariate analysis, resting TR velocity (p<0.0001), E/E' (p = 0.027), age and gender were the strongest predictors of PASP during exercise. CONCLUSION: Exercise-induced PH is common even in subjects with normal LVEF. It is strongly associated with E/E' ratio, TR velocity, age, systolic blood pressure during exercise and gender | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 490~494 | - |
dc.relation.isPartOf | HEART | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Flow Velocity | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Echocardiography, Doppler/methods | - |
dc.subject.MESH | Exercise/physiology* | - |
dc.subject.MESH | Exercise Test | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension, Pulmonary/diagnostic imaging | - |
dc.subject.MESH | Hypertension, Pulmonary/etiology* | - |
dc.subject.MESH | Hypertension, Pulmonary/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxygen/blood | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Stroke Volume* | - |
dc.subject.MESH | Tricuspid Valve Insufficiency/diagnostic imaging | - |
dc.subject.MESH | Tricuspid Valve Insufficiency/physiopathology | - |
dc.subject.MESH | Ventricular Function, Left* | - |
dc.title | Determinants of exercise-induced pulmonary hypertension in patients with normal left ventricular ejection fraction. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | J-W Ha | - |
dc.contributor.googleauthor | D Choi | - |
dc.contributor.googleauthor | S Park | - |
dc.contributor.googleauthor | C-Y Shim | - |
dc.contributor.googleauthor | J-M Kim | - |
dc.contributor.googleauthor | S-H Moon | - |
dc.contributor.googleauthor | H-J Lee | - |
dc.contributor.googleauthor | E-Y Choi | - |
dc.contributor.googleauthor | N Chung | - |
dc.identifier.doi | 10.1136/hrt.2007.139295 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04165 | - |
dc.contributor.localId | A04257 | - |
dc.relation.journalcode | J00976 | - |
dc.identifier.eissn | 1468-201X | - |
dc.identifier.pmid | 18653569 | - |
dc.identifier.url | http://heart.bmj.com/content/95/6/490.long | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Shim, Chi Young | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.alternativeName | Ha, Jong Won | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Shim, Chi Young | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Ha, Jong Won | - |
dc.citation.volume | 95 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 490 | - |
dc.citation.endPage | 494 | - |
dc.identifier.bibliographicCitation | HEART, Vol.95(6) : 490-494, 2009 | - |
dc.identifier.rimsid | 36679 | - |
dc.type.rims | ART | - |
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