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Association between blood pressure and carotid intima-media thickness.

Authors
 SUN MIN LIM  ;  HYEON CHANG KIM  ;  HOON SANG LEE  ;  JOO YOUNG LEE  ;  MINA SUH  ;  SONG VOGUE AHN 
Citation
 Journal of Pediatrics, Vol.154(5) : 667-671, 2009 
Journal Title
 Journal of Pediatrics 
ISSN
 0022-3476 
Issue Date
2009
MeSH
Adolescent ; Blood Glucose/analysis ; Blood Pressure* ; Carotid Arteries/diagnostic imaging* ; Cholesterol/blood ; Cohort Studies ; Cross-Sectional Studies ; Diastole ; Female ; Humans ; Korea ; Male ; Rural Population ; Sex Factors ; Systole ; Triglycerides/blood ; Tunica Intima/diagnostic imaging* ; Tunica Media/diagnostic imaging* ; Ultrasonography
Keywords
DBP ; Diastolic blood pressure ; HDL ; High-density lipoprotein ; IMT ; Intima-media thickness ; OR ; Odds ratio ; SBP ; Systolic blood pressure
Abstract
OBJECTIVE: To investigate the association between blood pressure and carotid intima-media thickness (IMT) in healthy adolescents. STUDY DESIGN: Study participants included 285 first-year high school students (mean age, 15.2 years) at a rural high school in Korea. Systolic and diastolic blood pressure (SBP and DBP) were measured with an oscillometric automated sphygmomanometer. The carotid arteries were evaluated with high-resolution B-mode ultrasound scanning. IMT value was determined with the average of the maximal IMT at each common carotid artery. Increased IMT was defined as sex-specific top quartile. The odds ratio (OR) for increased IMT per 1 SD increase of SBP and DBP was estimated after adjusting for age, sex, body mass index, waist circumference, fasting glucose level, and total/high-density lipoprotein cholesterol ratio. RESULTS: Adjusted OR for increased IMT was 1.70 (P = .003) per 12.4 mm Hg SBP and 1.25 (P = .125) per 7.0 mm Hg DBP. When the analyses were performed by sex, increased IMT was associated with both SBP (OR, 2.67; P = .003) and DBP (OR, 1.68; P = .019) in girls, but it was not associated with either SBP (OR, 1.46; P = .093) or DBP (OR, 0.99; P = .972) in boys. CONCLUSION: These results suggest that higher blood pressure level may be associated with increased carotid IMT in apparently healthy adolescents.
Full Text
http://www.sciencedirect.com/science/article/pii/S002234760800958X
DOI
10.1016/j.jpeds.2008.10.047
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Joo Young(이주영)
Yim, Sun Mie(임선미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103757
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