Cited 33 times in

Early clinical experience and outcome of helical tomotherapy for multiple metastatic lesions

DC Field Value Language
dc.contributor.author김용배-
dc.contributor.author서창옥-
dc.contributor.author성진실-
dc.contributor.author이익재-
dc.contributor.author이창걸-
dc.contributor.author조재호-
dc.contributor.author금기창-
dc.contributor.author김귀언-
dc.date.accessioned2015-04-24T16:33:47Z-
dc.date.available2015-04-24T16:33:47Z-
dc.date.issued2009-
dc.identifier.issn0360-3016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103747-
dc.description.abstractPURPOSE: To evaluate the feasibility of synchronous treatment of multiple metastatic lesions by helical tomotherapy. METHODS AND MATERIALS: Forty-two patients with multiple metastatic lesions were treated by helical tomotherapy from April 2006 to February 2007. Among these patients, 21 had metastatic bone disease. Subjective pain response was assessed using the visual analogue scales, and morbidity was evaluated by Common Terminology Criteria for Adverse Events v3.0. The correlation between the percentage of red bone marrow in the radiation field and the severity of leukocytopenia was analyzed. RESULTS: The median age was 57 years. Radiation dose to the gross tumor volume was 30-84 Gy, with a median fractional size of 3 Gy. Mean treatment time was 16 min and 1 sec. Treatment time and fraction size were modified because of poor performance status or hematologic toxicity in two patients. With regard to palliative effects for bone metastasis, 16 patients (76.2%) experienced positive pain relief. Four patients had Grade III leukocytopenia, and three had Grade IV leukocytopenia. In the multivariate logistic regression, red marrow percentage was the independent risk factor most associated with Grade III/IV leukocytopenia (p = 0.014). The tolerance cutoff point of red bone marrow was 26.8%, with a sensitivity and specificity of 85.7% and 85.7%, respectively. CONCLUSIONS: Helical tomotherapy was effective for symptom palliation and was feasible for patients with multiple metastatic diseases. The volume of red bone marrow, as well as performance status, must be taken into account to determine optimal treatment-
dc.description.statementOfResponsibilityopen-
dc.format.extent1517~1524-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenal Gland Neoplasms/radiotherapy-
dc.subject.MESHAdrenal Gland Neoplasms/secondary-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBone Marrow/pathology-
dc.subject.MESHBone Marrow/radiation effects*-
dc.subject.MESHBone Neoplasms/radiotherapy-
dc.subject.MESHBone Neoplasms/secondary-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLeukopenia/etiology-
dc.subject.MESHLeukopenia/pathology-
dc.subject.MESHLiver Neoplasms/radiotherapy-
dc.subject.MESHLiver Neoplasms/secondary-
dc.subject.MESHLung Neoplasms/radiotherapy-
dc.subject.MESHLung Neoplasms/secondary-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis/radiotherapy*-
dc.subject.MESHPalliative Care/methods*-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRadiotherapy, Intensity-Modulated/methods*-
dc.subject.MESHTreatment Outcome-
dc.titleEarly clinical experience and outcome of helical tomotherapy for multiple metastatic lesions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorIK JAE LEE-
dc.contributor.googleauthorJINSIL SEONG-
dc.contributor.googleauthorCHANG GEOL LEE-
dc.contributor.googleauthorYONG BAE KIM-
dc.contributor.googleauthorKI CHANG KEUM-
dc.contributor.googleauthorCHANG OK SUH-
dc.contributor.googleauthorGWI EON KIM-
dc.contributor.googleauthorJAEHO CHO-
dc.identifier.doi10.1016/j.ijrobp.2008.07.035-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03901-
dc.contributor.localIdA00744-
dc.contributor.localIdA01919-
dc.contributor.localIdA01956-
dc.contributor.localIdA03055-
dc.contributor.localIdA03240-
dc.contributor.localIdA00272-
dc.contributor.localIdA00321-
dc.relation.journalcodeJ01157-
dc.identifier.eissn1879-355X-
dc.identifier.pmid19084348-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0360301608031751-
dc.subject.keywordTomotherapy-
dc.subject.keywordRed bone marrow-
dc.subject.keywordMultiple metastases-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.citation.volume73-
dc.citation.number5-
dc.citation.startPage1517-
dc.citation.endPage1524-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.73(5) : 1517-1524, 2009-
dc.identifier.rimsid36665-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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