Cited 23 times in
The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.
DC Field | Value | Language |
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dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 한승진 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2015-04-24T16:33:37Z | - |
dc.date.available | 2015-04-24T16:33:37Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1096-7192 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103742 | - |
dc.description.abstract | OBJECTIVE: Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potential superoxide scavenger. We examined the relationship between the risk of NQO1 C609T polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes. METHODS: We recruited 601 (Seoul set) and 233 (Koyang set) unrelated patients with type 2 diabetes from independent groups. The C609T variant of NQO1 was genotyped by Taqman RT-PCR. Mean and maximum carotid intima-media thickness (IMT) and carotid artery plaques were measured by high-resolution ultrasonography. RESULTS: Patients with the T allele exhibited a higher prevalence of atherosclerotic plaques than non-T allele carriers in both sets (Seoul set vs. Koyang set, p=0.021, p=0.023, respectively). After adjusting for age, sex, duration of diabetes, systolic blood pressure, body mass index, current smoking, HDL-cholesterol, LDL-cholesterol and HbA1c, subjects with the T allele had a significantly higher risk of carotid artery plaques (Seoul set vs. Koyang set, OR=1.65, p=0.015; OR=2.00, p=0.037, respectively) than subjects with the CC genotype. CONCLUSION: These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MOLECULAR GENETICS AND METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | CarotidArtery, Common/pathology | - |
dc.subject.MESH | CarotidStenosis/complications* | - |
dc.subject.MESH | CarotidStenosis/enzymology* | - |
dc.subject.MESH | CarotidStenosis/genetics | - |
dc.subject.MESH | DiabetesMellitus,Type2/complications* | - |
dc.subject.MESH | DiabetesMellitus,Type2/enzymology* | - |
dc.subject.MESH | DiabetesMellitus,Type2/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NAD(P)H Dehydrogenase (Quinone)/genetics* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Tunica Intima/pathology | - |
dc.subject.MESH | Tunica Media/pathology | - |
dc.title | The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung Jin Han | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Hyeong Jin Kim | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.contributor.googleauthor | Sung Wan Chun | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Moonsuk Nam | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.1016/j.ymgme.2009.01.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04302 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A01158 | - |
dc.contributor.localId | A01248 | - |
dc.relation.journalcode | J02258 | - |
dc.identifier.eissn | 1096-7206 | - |
dc.identifier.pmid | 19251446 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1096719209000328 | - |
dc.subject.keyword | Carotid atherosclerosis | - |
dc.subject.keyword | Carotid artery plaque | - |
dc.subject.keyword | NQO1 | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Han, Seung Jin | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Nam, Moon Suk | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Han, Seung Jin | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Nam, Moon Suk | - |
dc.citation.volume | 97 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | MOLECULAR GENETICS AND METABOLISM, Vol.97(1) : 85-90, 2009 | - |
dc.identifier.rimsid | 36662 | - |
dc.type.rims | ART | - |
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