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G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

Authors
 Woo Sun Kwon  ;  Sun Young Rha  ;  Hei-Cheul Jeung  ;  Joong Bae Ahn  ;  Jae Joon Jung  ;  Sung Hoon Noh  ;  Hyun Cheol Chung 
Citation
 CANCER LETTERS, Vol.277(2) : 155-163, 2009 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2009
MeSH
ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1/genetics* ; Antineoplastic Agents, Phytogenic/pharmacology* ; Asian Continental Ancestry Group* ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Gene Expression Profiling ; Haplotypes* ; Humans ; Paclitaxel/pharmacology* ; Polymorphism, Single Nucleotide*
Keywords
ABCB1 ; G–T haplotype ; Paclitaxel sensitivity ; Expression profile
Abstract
At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p=0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p=0.018). A higher IC(50) was found in GG than GT/A genotype (p=0.02) and in G-C than G-T haplotype (p=0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p=0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383508009300
DOI
10.1016/j.canlet.2008.12.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Woo Sun(권우선)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103724
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