153 313

Cited 9 times in

Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women.

Authors
 Jae Woong Sull  ;  Hee Jin Kim  ;  Ji Eun Yun  ;  Grace Kim  ;  Eun Jung Park  ;  Soriul Kim  ;  Hee Yeon Lee  ;  Sun Ha Jee 
Citation
 EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol.160(1) : 39-43, 2009 
Journal Title
EUROPEAN JOURNAL OF ENDOCRINOLOGY
ISSN
 0804-4643 
Issue Date
2009
MeSH
Adiponectin/blood ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; Body Mass Index ; Cholesterol/blood ; Cross-Sectional Studies ; Diabetes Mellitus/blood* ; Diabetes Mellitus/genetics ; Female ; Humans ; Insulin Resistance* ; Korea ; Linear Models ; Male ; Middle Aged ; Triglycerides/blood ; Waist Circumference ; Young Adult
Abstract
BACKGROUND: Adiponectin has been reported as a new risk factor for the development of diabetes. However, it is not clear whether adiponectin levels are associated with family history of diabetes (FHD). OBJECTIVE: The objective of this study was to measure the independent association of serum adiponectin with FHD in relation to insulin resistance and obesity. METHODS: In 2006, a cross-sectional study was conducted in which waist circumference (WC), body mass index (BMI), and serum adiponectin were measured in 5919 healthy Korean men and women. Multiple linear regression models were used to assess the association of serum adiponectin levels with FHD. The population was classified into two groups according to median values for each of the following variables: WC, BMI, and homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: The positive FHD group had higher HOMA-IR and lower adiponectin levels in both men and women than those without FHD. Adiponectin levels were significantly associated with FHD in men and women respectively, after adjusting for age, BMI, and alcohol consumption (P=0.0123 and 0.0004). The relationship between adiponectin and FHD was similar between the high and low insulin resistance, BMI, and WC groups in male non-smokers and in all Korean women. CONCLUSION: These results confirm that adiponectin levels are associated with FHD. These data also suggest that the association of serum adiponectin with FHD may be independent of obesity and insulin resistance.
Files in This Item:
T200900953.pdf Download
DOI
10.1530/EJE-08-0603
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Sull, Jae Woong(설재웅)
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103710
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links