Cited 53 times in
Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct.
DC Field | Value | Language |
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dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2015-04-24T16:31:55Z | - |
dc.date.available | 2015-04-24T16:31:55Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0969-7128 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103688 | - |
dc.description.abstract | The development of clinically beneficial myocardial gene therapy has been slowed by reliance on the use of viral carriers and non-physiologic, constitutive gene expression. To specifically address these issues, we have developed a non-viral gene carrier, water-soluble lipopolymer (WSLP), and an ischemia-inducible plasmid construct expressing vascular endothelial growth factor (VEGF), pRTP801-VEGF, to treat myocardial ischemia and infarction. Rabbits underwent ligation of the circumflex artery followed by injection of (a) an ischemia-inducible VEGF gene construct in a WSLP carrier; (b) a constitutively expressed, or unregulated, SV-VEGF gene construct in a WSLP carrier; (c) WSLP carrier alone; or (d) no injection therapy. Following 4 weeks treatment, ligation alone resulted in infarction of 48+/-7% of the left ventricle. With injection of WSLP carrier alone, 49+/-6% of the left ventricle was infarcted (P=NS). The constitutively expressed gene construct, SV-VEGF, reduced the infarct size to 32+/-7% of the left ventricle (P=0.007). The ischemia-inducible gene construct, RTP801-VEGF, further reduced the infarct size to 13+/-4% of the left ventricle (P<0.001). The use of a non-viral carrier to deliver an ischemia-inducible VEGF construct is effective in the treatment of acutely ischemic myocardium. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 127~135 | - |
dc.relation.isPartOf | GENE THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Genetic Therapy/methods* | - |
dc.subject.MESH | Injections | - |
dc.subject.MESH | Models, Animal | - |
dc.subject.MESH | Myocardial Infarction/metabolism | - |
dc.subject.MESH | Myocardial Infarction/pathology | - |
dc.subject.MESH | Myocardial Infarction/therapy* | - |
dc.subject.MESH | Myocardium/metabolism* | - |
dc.subject.MESH | Myocardium/pathology | - |
dc.subject.MESH | Polymers | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Transfection/methods* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/analysis | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics* | - |
dc.title | Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | JW Yockman | - |
dc.contributor.googleauthor | D Choi | - |
dc.contributor.googleauthor | MG Whitten | - |
dc.contributor.googleauthor | CW Chang | - |
dc.contributor.googleauthor | A Kastenmeier | - |
dc.contributor.googleauthor | H Erickson | - |
dc.contributor.googleauthor | A Albanil | - |
dc.contributor.googleauthor | M Lee | - |
dc.contributor.googleauthor | SW Kim | - |
dc.contributor.googleauthor | DA Bull | - |
dc.identifier.doi | 10.1038/gt.2008.146 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00924 | - |
dc.identifier.eissn | 1476-5462 | - |
dc.identifier.pmid | 18784748 | - |
dc.identifier.url | http://www.nature.com/gt/journal/v16/n1/full/gt2008146a.html | - |
dc.subject.keyword | ischemia-inducible | - |
dc.subject.keyword | polymer carrier | - |
dc.subject.keyword | myocardial infarction | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | angiogenesis | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 135 | - |
dc.identifier.bibliographicCitation | GENE THERAPY, Vol.16(1) : 127-135, 2009 | - |
dc.identifier.rimsid | 36628 | - |
dc.type.rims | ART | - |
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