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N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-24T16:31:51Z | - |
dc.date.available | 2015-04-24T16:31:51Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103686 | - |
dc.description.abstract | BACKGROUND: Increased level of N-terminal pro-B type natriuretic peptide (NT-proBNP) is known to be associated with adverse outcome in patients with acute coronary syndrome. We evaluated early outcomes of patients with acute ST-elevated myocardial infarction (STEMI) according to the level of NT-proBNP as a substudy of Korean Acute Myocardial Infarction Registry (KAMIR). METHODS: Study population consisted of 1052 consecutive patients (mean 61.3+/-12.8 years old, male 73.2%) with STEMI of onset <12 h who underwent primary percutaneous coronary intervention (PCI) and who had baseline NT-proBNP level by electrochemiluminescence immnunoassay (ECLIA, NT-proBNP kit, Roche Diagnostics, Mannheim, Germany). The study subjects were divided into two groups according to the level of serum NT-proBNP. RESULTS: Patients with NT-proBNP level >991 pg/mL (n=329, 57.1% male) had lower left ventricle ejection fraction (LVEF) (47.8+/-11.8% vs. 53.0+/-10.8%, p<0.001), needed longer intensive care (3.7+/-3.6 days vs. 2.8+/-2.4 days, p<0.001) and had higher in-hospital mortality (1.3% vs. 7.4%, p<0.001) than those with NT-proBNP level<or=991 pg/mL (n=723, 80.5% male). Multiple logistic regression analysis revealed that the independent predictors of in-hospital mortality were LVEF<45% (OR 5.43, 95% CI 1.71 to 17.29, p=0.004), elevated NT-proBNP (>991 pg/mL) (OR 3.70, 95% CI 1.14 to 12.03, p=0.030), old age (>or=70 years) (OR 4.71, 95% CI 1.43 to 15.52, p=0.011), advanced Killip class (>1) (OR 4.96, 95% CI 1.58 to 15.53, p=0.006), male gender (OR 5.67, 95% CI 1.45 to 22.21, p=0.013) and TIMI flow 0 before PCI (OR 5.04, 95% CI 1.08 to 23.41, p=0.039). CONCLUSIONS: This study suggests that baseline NT-proBNP level is associated with short term mortality in patients with STEMI underwent primary PCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 173~178 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/adverse effects | - |
dc.subject.MESH | Angioplasty, Balloon, Coronary/mortality* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/blood* | - |
dc.subject.MESH | Myocardial Infarction/mortality | - |
dc.subject.MESH | Myocardial Infarction/therapy | - |
dc.subject.MESH | Natriuretic Peptide, Brain/blood* | - |
dc.subject.MESH | Peptide Fragments/blood* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Taek Geun Kwon | - |
dc.contributor.googleauthor | Jang Ho Bae | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Young Jo Kim | - |
dc.contributor.googleauthor | Seung Ho Hur | - |
dc.contributor.googleauthor | In Whan Seong | - |
dc.contributor.googleauthor | Myeong Chan Cho | - |
dc.contributor.googleauthor | Ki Bae Seung | - |
dc.contributor.googleauthor | Yang Soo Jang | - |
dc.contributor.googleauthor | Seung Jung Park | - |
dc.identifier.doi | 10.1016/j.ijcard.2007.12.022 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 18281115 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S016752730800003X | - |
dc.subject.keyword | N-terminal pro-B type natriuretic peptide | - |
dc.subject.keyword | Myocardial infarction | - |
dc.subject.keyword | Percutaneous coronary intervention | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 133 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 178 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.133(2) : 173-178, 2009 | - |
dc.identifier.rimsid | 36626 | - |
dc.type.rims | ART | - |
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