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Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author길혜금-
dc.contributor.author나군호-
dc.contributor.author심재광-
dc.contributor.author오영준-
dc.contributor.author조장은-
dc.date.accessioned2015-04-24T16:31:08Z-
dc.date.available2015-04-24T16:31:08Z-
dc.date.issued2009-
dc.identifier.issn0090-4295-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103664-
dc.description.abstractOBJECTIVES: To investigate the renoprotective effect of nicardipine in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALRP) in a prospective trial. Superior visualization of the increasingly performed RALRP requires pneumoperitoneum and extreme head-down tilt, both of which are associated with a decrease in postoperative renal function. Nicardipine causes preferential dilation of the renal arterioles and attenuates renal dysfunction after cardiac surgery. METHODS: After we obtained institutional review board approval, we randomly treated 100 patients undergoing RALRP with a continuous infusion of nicardipine at a rate of 0.5 microg/kg/min (nicardipine group, n = 50) or with normal saline (control group, n = 50) during surgery. We measured the serum creatinine (Cr) level and estimated glomerular filtration rate (eGFR) 1 day before surgery and the first and third postoperative days (POD 1 and 3, respectively). RESULTS: Patients' characteristics and operative data were similar between groups. The serum Cr was significantly higher and the eGFR was significantly lower in the control group at POD 1. The number of patients having renal insufficiency (eGFR < 60 mL/min/1.73 m(2)) and abnormal serum creatinine level (>1.4 mg/dL) was significantly greater in the control group (9 vs 1, and 4 vs none, respectively) at POD 1. CONCLUSIONS: Continuous infusion of low-dose nicardipine during RALRP seems to offset the deleterious effects of inevitable pneumoperitoneum and extreme head-down tilt on renal function in preserving the eGFR and attenuating the development of renal insufficiency in the immediate postoperative period.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1056~1060-
dc.relation.isPartOfUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlomerular Filtration Rate/drug effects*-
dc.subject.MESHHumans-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHKidney Function Tests-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNicardipine/therapeutic use*-
dc.subject.MESHPerioperative Care/methods-
dc.subject.MESHPneumoperitoneum, Artificial-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHProbability-
dc.subject.MESHProspective Studies-
dc.subject.MESHProstatectomy/instrumentation-
dc.subject.MESHProstatectomy/methods*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHReference Values-
dc.subject.MESHRenal Insufficiency/prevention & control-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRobotics*-
dc.subject.MESHStatistics, Nonparametric-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVasodilator Agents/therapeutic use-
dc.titleEffect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJang Eun Cho-
dc.contributor.googleauthorJae Kwang Shim-
dc.contributor.googleauthorJae Hyun Chang-
dc.contributor.googleauthorYoung Jun Oh-
dc.contributor.googleauthorHae Keum Kil-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorYoung Lan Kwak-
dc.identifier.doi10.1016/j.urology.2008.08.490-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA00283-
dc.contributor.localIdA01227-
dc.contributor.localIdA02205-
dc.contributor.localIdA02389-
dc.contributor.localIdA03893-
dc.relation.journalcodeJ02775-
dc.identifier.eissn1527-9995-
dc.identifier.pmid19394503-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0090429508015239-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKil, Hae Keum-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameOh, Young Jun-
dc.contributor.alternativeNameCho, Jang Eun-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorKil, Hae Keum-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorOh, Young Jun-
dc.contributor.affiliatedAuthorCho, Jang Eun-
dc.citation.volume73-
dc.citation.number5-
dc.citation.startPage1056-
dc.citation.endPage1060-
dc.identifier.bibliographicCitationUROLOGY, Vol.73(5) : 1056-1060, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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