207 402

Cited 11 times in

The Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris

DC Field Value Language
dc.contributor.author유욱-
dc.contributor.author이상은-
dc.date.accessioned2015-04-24T16:29:15Z-
dc.date.available2015-04-24T16:29:15Z-
dc.date.issued2009-
dc.identifier.issn1013-9087-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103605-
dc.description.abstractBACKGROUND: A difference of the interleukin-18 (IL-18) mRNA expression among several proinflammatory genes was previously observed between large plaque (LP) psoriasis patients (more than 5 cm lesions are typical) and small plaque (SP) psoriasis patients (1~2 cm lesions are typical). Therefore, it is necessary to test whether there is any difference in the expression of the genes that activate IL-18 or the expression of genes that are induced by IL-18. OBJECTIVE: To test the differential mRNA expressions of caspase-1, STAT-6, MMP-1, MMP-2, MMP-9 and TIMP-1 according to the clinical types of psoriasis vulgaris lesions in Korean patients, we have analyzed the skin samples of psoriasis vulgaris patients. METHODS: the total cellular RNA of skin samples from groups of patient with LP and SP psoriasis was analyzed by performing real-time PCR (the Taqman method) to compare the differences in the mRNA expressions. RESULTS: the caspase-1 and STAT-6 mRNA expression levels from the SP lesional skin of the patients were increased compared with the caspase-1 and STAT-6 mRNA expression levels from SP non-lesional skin or normal skin, but these expression levels from the SP non-lesional skin were not significantly different from those of the LP non-lesional skin. Among MMP-1, MMP-2, MMP-9 and TIMP-1, the expressions of MMP-1, MMP-2 and MMP-9 mRNA were increased in the SP lesional skin compared with those of the SP non-lesional skin. the MMP-1 mRNA expressions in both the LP and SP lesional skin were increased compared with those in the normal skin (p=0.028 and p=0.007 respectively). the MMP-9 mRNA expression in the LP non-lesional skin was elevated compared with the MMP-9 mRNA expression in the SP non-lesional skin (p=0.047). the TIMP-1 mRNA expression levels from the non-lesional skin and the lesional skin of the psoriasis patients and the normal skin samples were not significantly different. CONCLUSION: the increased expression of MMP-9 mRNA in the LP non-lesional skin compared to that of the SP non-lesional skin in the psoriatic skin suggests that the increased MMP-9 mRNA expression is related to the large size type of lesion.-
dc.description.statementOfResponsibilityopen-
dc.format.extent27~34-
dc.relation.isPartOfANNALS OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorWook Lew-
dc.identifier.doi10.5021/ad.2009.21.1.27-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02487-
dc.contributor.localIdA02826-
dc.relation.journalcodeJ00158-
dc.identifier.eissn2005-3894-
dc.identifier.pmid20548851-
dc.subject.keywordLarge plaque type-
dc.subject.keywordMatrix metalloproteinase-9-
dc.subject.keywordPsoriasis vulgaris-
dc.subject.keywordSmall plaque type-
dc.contributor.alternativeNameLew, Wook-
dc.contributor.alternativeNameLee, Sang Eun-
dc.contributor.affiliatedAuthorLew, Wook-
dc.contributor.affiliatedAuthorLee, Sang Eun-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage27-
dc.citation.endPage34-
dc.identifier.bibliographicCitationANNALS OF DERMATOLOGY, Vol.21(1) : 27-34, 2009-
dc.identifier.rimsid37947-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.