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Vancomycin-resistant enterococci bacteremia: risk factors for mortality and influence of antimicrobial therapy on clinical outcome

DC Field Value Language
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author송영구-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author이한성-
dc.contributor.author정수진-
dc.contributor.author진범식-
dc.contributor.author최준용-
dc.contributor.author최희경-
dc.contributor.author한상훈-
dc.date.accessioned2015-04-24T16:27:32Z-
dc.date.available2015-04-24T16:27:32Z-
dc.date.issued2009-
dc.identifier.issn0163-4453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103550-
dc.description.abstractOBJECTIVES: This study evaluated the effects of antimicrobial treatment against vancomycin-resistant enterococci (VRE) and delayed administration of anti-VRE therapy on mortality, and determined independent risk factors for delayed all-cause mortality of VRE bacteremia patients. METHODS: Over 10 years, 153 patients with clinically significant monomicrobial VRE bacteremia were identified among a total of 2834 patients in a VRE cohort. The main outcomes were immediate (7-day) and delayed (28-day, 60-day) all-cause mortality. RESULTS: The 7-day (P<0.001) and 28-day (P=0.041) mortalities were lower in the group receiving anti-VRE therapy, but the 60-day mortality (P=0.113) was unaffected. The mortalities of patients receiving anti-VRE therapy later than 72h after the onset of bacteremia were no different from that of patients receiving treatment within 72h. Both a higher APACHE II score (hazard ratio [HR], 1.10; P<0.001 and HR, 1.12; P<0.001, respectively) and the presence of septic shock at the onset of bacteremia (HR, 1.91; P=0.047 and HR, 1.78; P=0.034, respectively) were independent risk factors for 28-day and 60-day mortality. CONCLUSION: These findings suggest that in spite of antibiotic therapy against VRE, patients with VRE bacteremia eventually have a higher risk of death because of severe illness at the onset of bacteremia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent182~190-
dc.relation.isPartOfJOURNAL OF INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAPACHE-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHBacteremia/drug therapy*-
dc.subject.MESHBacteremia/microbiology*-
dc.subject.MESHBacteremia/mortality-
dc.subject.MESHEnterococcus/drug effects*-
dc.subject.MESHEnterococcus/isolation & purification-
dc.subject.MESHFemale-
dc.subject.MESHGram-Positive Bacterial Infections/drug therapy*-
dc.subject.MESHGram-Positive Bacterial Infections/microbiology*-
dc.subject.MESHGram-Positive Bacterial Infections/mortality-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHShock, Septic-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVancomycin Resistance*-
dc.titleVancomycin-resistant enterococci bacteremia: risk factors for mortality and influence of antimicrobial therapy on clinical outcome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorHan Sung Lee-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorHee Kyoung Choi-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1016/j.jinf.2009.01.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA02037-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03277-
dc.contributor.localIdA03638-
dc.contributor.localIdA03981-
dc.contributor.localIdA04191-
dc.contributor.localIdA04228-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ01452-
dc.identifier.eissn1532-2742-
dc.identifier.pmid19233476-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S016344530900036X-
dc.subject.keywordVancomycin-resistant enterococci-
dc.subject.keywordBacteremia-
dc.subject.keywordMortality-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Han Sung-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameChoi, Hee Kyoung-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Han Sung-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorChoi, Hee Kyoung-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume58-
dc.citation.number3-
dc.citation.startPage182-
dc.citation.endPage190-
dc.identifier.bibliographicCitationJOURNAL OF INFECTION, Vol.58(3) : 182-190, 2009-
dc.identifier.rimsid37919-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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