Cited 4 times in
Efficacy of a negative conversion trial and subsequent living donor kidney transplant outcome in recipients with a positive lymphocyte crossmatch
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 장혜경 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 주만기 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 김명수 | - |
dc.date.accessioned | 2015-04-24T16:26:31Z | - |
dc.date.available | 2015-04-24T16:26:31Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1660-8151 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103518 | - |
dc.description.abstract | BACKGROUND: Patients with a positive lymphocyte crossmatch (LCX) do not undergo kidney transplantation. In such patients, a negative conversion protocol consisting of intravenous immunoglobulin (IVIG), plasmapheresis, and potent immunosuppressant is one of the options for transplantation. METHODS: 14 patients who showed a positive LCX with living donors underwent a trial of negative conversion between January 2002 and July 2007. Plasmapheresis was performed every other day, up to 6 times maximum. IVIG was infused after plasmapheresis, with a total dose of 500 mg/kg divided over 6 days. Kidney transplantation was performed immediately after negative conversion. Anti-thymocyte globulin (ATG) or OKT3 induction therapy was used with the combination of tacrolimus, mycophenolate mofetil, and prednisone in the perioperative period. RESULTS: Negative conversion of LCX was achieved in 13 of 14 patients (92.9%). Transplantations were performed successfully in these 13 patients without hyperacute rejection. Four recipients developed acute rejection, which was well controlled by steroid pulse therapy. During the follow-up periods of 45.4 +/- 22.0 months, all recipients except 1 showed excellent graft function. CONCLUSION: Selected patients with a positive LCX can undergo successful transplantation using plasmapheresis, IVIG, and potent immunosuppressants. Recipients with negative conversion of LCX showed acceptable posttransplant results | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | C49~C54 | - |
dc.relation.isPartOf | NEPHRON | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antilymphocyte Serum/therapeutic use | - |
dc.subject.MESH | B-Lymphocytes/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft Rejection/etiology | - |
dc.subject.MESH | Graft Rejection/prevention & control | - |
dc.subject.MESH | Histocompatibility Testing* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulins, Intravenous/therapeutic use* | - |
dc.subject.MESH | Immunosuppression/methods* | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Isoantibodies/blood* | - |
dc.subject.MESH | Kidney Transplantation/immunology* | - |
dc.subject.MESH | Living Donors* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Muromonab-CD3/therapeutic use | - |
dc.subject.MESH | Mycophenolic Acid/administration & dosage | - |
dc.subject.MESH | Mycophenolic Acid/analogs & derivatives | - |
dc.subject.MESH | Mycophenolic Acid/therapeutic use | - |
dc.subject.MESH | Plasmapheresis* | - |
dc.subject.MESH | Prednisone/administration & dosage | - |
dc.subject.MESH | Prednisone/therapeutic use | - |
dc.subject.MESH | Premedication | - |
dc.subject.MESH | Preoperative Care/methods* | - |
dc.subject.MESH | Reoperation | - |
dc.subject.MESH | T-Lymphocytes/immunology | - |
dc.subject.MESH | Tacrolimus/administration & dosage | - |
dc.subject.MESH | Tacrolimus/therapeutic use | - |
dc.subject.MESH | Transplantation, Homologous/immunology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Efficacy of a negative conversion trial and subsequent living donor kidney transplant outcome in recipients with a positive lymphocyte crossmatch | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Man Ki Ju | - |
dc.contributor.googleauthor | Hye Kyung Chang | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.identifier.doi | 10.1159/000178979 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03494 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A03949 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J02318 | - |
dc.identifier.eissn | 2235-3186 | - |
dc.identifier.pmid | 19052470 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/178979 | - |
dc.subject.keyword | Intravenous immunoglobulin | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Plasmapheresis | - |
dc.subject.keyword | Positive lymphocyte crossmatch | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Chang, Hye Kyung | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Joo, Man Ki | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Chang, Hye Kyung | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Joo, Man Ki | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 111 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 54 | - |
dc.identifier.bibliographicCitation | NEPHRON, Vol.111(1) : 49-54, 2009 | - |
dc.identifier.rimsid | 36060 | - |
dc.type.rims | ART | - |
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