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Endometrial osteopontin mRNA expression and plasma osteopontin levels are increased in patients with endometriosis
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.contributor.author | 김혜연 | - |
dc.contributor.author | 남안나 | - |
dc.contributor.author | 박기현 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 조동제 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2015-04-24T16:25:57Z | - |
dc.date.available | 2015-04-24T16:25:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1046-7408 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103501 | - |
dc.description.abstract | PROBLEM: The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels in patients with endometriosis. METHOD OF STUDY: A total of 79 patients with histologically confirmed endometriosis and 43 patients without endometriosis participated in this study. OPN mRNA expression in endometrial tissues was measured by real-time quantitative polymerase chain reaction (PCR) and plasma concentrations of OPN were quantified using a specific commercial sandwich enzyme-linked immunosorbent assays (ELISA). RESULTS: Osteopontin mRNA expression in endometrial tissue was significantly higher in women with endometriosis than in controls (P = 0.010). The mean plasma levels of OPN (mean +/- S.E.M.) in patients with endometriosis and controls were 407.31 +/- 37.80 ng/mL and 165.84 +/- 19.29 ng/mL, respectively (P < 0.001). Receiver operating characteristic (ROC) analysis for plasma OPN revealed an area under the curve (AUC) of 0.894, with a sensitivity of 93.0%, specificity of 72.4%, positive likelihood ratio of 3.37, and negative likelihood ratio of 0.1 using a cut-off value of 167.68 ng/mL. CONCLUSION: Osteopontin may be involved in the pathogenesis of endometriosis and plasma OPN may be a useful non-invasive marker for the diagnosis of endometriosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 286~293 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | CA-125 Antigen/genetics | - |
dc.subject.MESH | CA-125 Antigen/metabolism* | - |
dc.subject.MESH | Endometriosis/diagnosis | - |
dc.subject.MESH | Endometriosis/metabolism* | - |
dc.subject.MESH | Endometriosis/pathology | - |
dc.subject.MESH | Endometriosis/physiopathology | - |
dc.subject.MESH | Endometrium/metabolism* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Osteopontin/genetics | - |
dc.subject.MESH | Osteopontin/metabolism* | - |
dc.subject.MESH | RNA, Messenger/analysis | - |
dc.subject.MESH | ROC Curve | - |
dc.title | Endometrial osteopontin mRNA expression and plasma osteopontin levels are increased in patients with endometriosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young Sun Ahn | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Anna Nam | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Ki Hyun Park | - |
dc.contributor.googleauthor | Dong Jae Cho | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 10.1111/j.1600-0897.2009.00692.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01257 | - |
dc.contributor.localId | A01450 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03814 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J00111 | - |
dc.identifier.eissn | 1600-0897 | - |
dc.identifier.pmid | 19260859 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2009.00692.x/abstract | - |
dc.subject.keyword | Endometriosis | - |
dc.subject.keyword | endometrium | - |
dc.subject.keyword | mRNA | - |
dc.subject.keyword | osteopontin | - |
dc.subject.keyword | plasma | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Nam, An Na | - |
dc.contributor.alternativeName | Park, Ki Hyun | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Cho, Dong Je | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Nam, An Na | - |
dc.contributor.affiliatedAuthor | Park, Ki Hyun | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Cho, Dong Je | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.citation.volume | 61 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 286 | - |
dc.citation.endPage | 293 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.61(4) : 286-293, 2009 | - |
dc.identifier.rimsid | 36047 | - |
dc.type.rims | ART | - |
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