Cited 19 times in
Identification of differentially expressed genes in papillary thyroid cancers
DC Field | Value | Language |
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dc.contributor.author | 이기영 | - |
dc.date.accessioned | 2015-04-24T16:25:51Z | - |
dc.date.available | 2015-04-24T16:25:51Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103498 | - |
dc.description.abstract | PURPOSE: Techniques designed to identify differentially expressed genes (DEGs) in tumors have become important in modern pathology. Genefishing technique using the annealing control primer (ACP) system has recently been developed to screen for DEG transcripts. We tried to identify DEGs involved in papillary thyroid cancer (PTC) by using Genefishing technique. MATERIALS AND METHODS: We utilized a new differential display method, designated with Genefishing technique, to analyze DEGs in 21 cases of PTCs. RESULTS: Comparing the gene expression profiles between PTC and normal thyroid, we detected 17 genes that were differentially expressed in PTCs and performed cloning with sequencing in 10 genes. We confirmed the expression patterns of 2 DEGs by RT-PCR assay and identified the same results in 17 out of 21 (81%) PTCs. The 2 DEGs over-expressed in PTCs were identified as DC-STAMP and type I collagen A1. They are novel genes identified first in PTCs. CONCLUSION: We confirmed 2 DEGs in PTCs as DC-STAMP and type I collagen A1 by using Genefishing technique. Although the detailed functions of those 2 genes and their products remain to be determined, the genes will provide insights into mechanisms of carcinogenesis or tumor progression in PTCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 60~67 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Papillary/genetics* | - |
dc.subject.MESH | Collagen Type I/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Proteins/genetics* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Thyroid Neoplasms/genetics* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Identification of differentially expressed genes in papillary thyroid cancers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Ki-Young Lee | - |
dc.contributor.googleauthor | Song Mei Huang | - |
dc.contributor.googleauthor | Shengjin Li | - |
dc.contributor.googleauthor | Jin-Man Kim | - |
dc.identifier.doi | 10.3349/ymj.2009.50.1.60 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02695 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 19259350 | - |
dc.subject.keyword | Papillary thyroid cancer | - |
dc.subject.keyword | dendritic cell-specific transmembrane protein | - |
dc.subject.keyword | differentially expressed genes | - |
dc.subject.keyword | type I collagen A1 | - |
dc.contributor.alternativeName | Lee, Ki Young | - |
dc.contributor.affiliatedAuthor | Lee, Ki Young | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 60 | - |
dc.citation.endPage | 67 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.50(1) : 60-67, 2009 | - |
dc.identifier.rimsid | 36044 | - |
dc.type.rims | ART | - |
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