Cited 16 times in
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유리 | - |
dc.contributor.author | 유미영 | - |
dc.contributor.author | 전부남 | - |
dc.contributor.author | 최원일 | - |
dc.contributor.author | 허만욱 | - |
dc.date.accessioned | 2015-04-24T16:25:22Z | - |
dc.date.available | 2015-04-24T16:25:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103484 | - |
dc.description.abstract | FBI-1, a member of the POK (POZ and Kruppel) family of transcription factors, plays a role in differentiation, oncogenesis, and adipogenesis. eEF1A is a eukaryotic translation elongation factor involved in several cellular processes including embryogenesis, oncogenic transformation, cell proliferation, and cytoskeletal organization. CCS-3, a potential cervical cancer suppressor, is an isoform of eEF1A. We found that eEF1A forms a complex with FBI-1 by co-immunoprecipitation, SDS-PAGE, and MALDI-TOF Mass analysis of the immunoprecipitate. GST fusion protein pull-downs showed that FBI-1 directly interacts with eEF1A and CCS-3 via the zinc finger and POZ-domain of FBI-1. FBI-1 co-localizes with either eEF1A or CCS-3 at the nuclear periplasm. CCS-3 enhances transcriptional repression of the p21CIP1 gene (hereafter referred to as p21) by FBI-1. The POZ-domain of FBI-1 interacts with the co-repressors, SMRT and BCoR. We found that CCS-3 also interacts with the co-repressors independently. The molecular interaction between the co-repressors and CCS-3 at the POZ-domain of FBI-1 appears to enhance FBI-1 mediated transcriptional repression. Our data suggest that CCS-3 may be important in cell differentiation, tumorigenesis, and oncogenesis by interacting with the proto-oncogene FBI-1 and transcriptional co-repressors | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 359~370 | - |
dc.relation.isPartOf | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p21/genetics | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p21/metabolism* | - |
dc.subject.MESH | DNA-Binding Proteins/genetics | - |
dc.subject.MESH | DNA-Binding Proteins/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoprecipitation | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Peptide Elongation Factor 1/genetics | - |
dc.subject.MESH | Peptide Elongation Factor 1/metabolism* | - |
dc.subject.MESH | Protein Isoforms/genetics | - |
dc.subject.MESH | Protein Isoforms/metabolism | - |
dc.subject.MESH | Protein Structure, Tertiary | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.subject.MESH | Transcription, Genetic | - |
dc.title | Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A). | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Won-Il Choi | - |
dc.contributor.googleauthor | Youngsoo Kim | - |
dc.contributor.googleauthor | Yuri Kim | - |
dc.contributor.googleauthor | Mi-young Yu | - |
dc.contributor.googleauthor | Jungeun Park | - |
dc.contributor.googleauthor | Choong-Eun Lee | - |
dc.contributor.googleauthor | Bu-Nam Jeon | - |
dc.contributor.googleauthor | Dong-In Koh | - |
dc.contributor.googleauthor | Man-Wook Hur | - |
dc.identifier.doi | 10.1159/000218182 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02465 | - |
dc.contributor.localId | A03517 | - |
dc.contributor.localId | A04126 | - |
dc.contributor.localId | A04350 | - |
dc.contributor.localId | A00778 | - |
dc.relation.journalcode | J00501 | - |
dc.identifier.eissn | 1421-9778 | - |
dc.identifier.pmid | 19471103 | - |
dc.identifier.url | http://www.karger.com/Article/Abstract/218182 | - |
dc.subject.keyword | eEF1A | - |
dc.subject.keyword | CCS-3 | - |
dc.subject.keyword | Transcription | - |
dc.subject.keyword | Repression | - |
dc.subject.keyword | FBI-1 | - |
dc.subject.keyword | p21 | - |
dc.subject.keyword | Pokemon | - |
dc.subject.keyword | POZ domain | - |
dc.subject.keyword | Co-repressors | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.alternativeName | Yu, Mi Young | - |
dc.contributor.alternativeName | Jeon, Bu Nam | - |
dc.contributor.alternativeName | Choi, Won Il | - |
dc.contributor.alternativeName | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Yu, Mi Young | - |
dc.contributor.affiliatedAuthor | Jeon, Bu Nam | - |
dc.contributor.affiliatedAuthor | Choi, Won Il | - |
dc.contributor.affiliatedAuthor | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Kim, Yu Ri | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4-6 | - |
dc.citation.startPage | 359 | - |
dc.citation.endPage | 370 | - |
dc.identifier.bibliographicCitation | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, Vol.23(4-6) : 359-370, 2009 | - |
dc.identifier.rimsid | 36032 | - |
dc.type.rims | ART | - |
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