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Nanograting-based plasmon enhancement for total internal reflection fluorescence microscopy of live cells

Authors
 Kyujung Kim  ;  Dong Jun Kim  ;  Eun-Jin Cho  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Donghyun Kim 
Citation
 NANOTECHNOLOGY, Vol.20(1) : 015202, 2009 
Journal Title
NANOTECHNOLOGY
ISSN
 0957-4484 
Issue Date
2009
MeSH
Cell Line, Tumor ; Humans ; Image Processing, Computer-Assisted ; Microscopy, Fluorescence/methods* ; Microscopy, Interference/methods* ; Quantum Dots ; Sensitivity and Specificity
Abstract
We investigated evanescent field enhancement based on subwavelength nanogratings for improved sensitivity in total internal reflection microscopy of live cells. the field enhancement is associated with subwavelength-grating-coupled plasmon excitation. An optimum sample employed a silver grating on a silver film and an SF10 glass substrate. Field intensity was enhanced by approximately 90% when measured by fluorescent excitation of microbeads relative to that on a bare prism as a control, which is in good agreement with numerical results. the subwavelength-grating-mediated field enhancement was also applied to live cell imaging of quantum dots, which confirmed the sensitivity enhancement qualitatively.
Full Text
http://stacks.iop.org/0957-4484/20/015202
DOI
10.1088/0957-4484/20/1/015202
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Cho, Eun Jin(조은진)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103479
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