Cited 24 times in
Interleukin-6 (IL-6) -572C-->G promoter polymorphism is associated with type 2 diabetes risk in Koreans
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-24T16:23:37Z | - |
dc.date.available | 2015-04-24T16:23:37Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103431 | - |
dc.description.abstract | OBJECTIVE: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. SUBJECTS: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. MEASUREMENTS: We examined IL-6 -174G-->C, -572C-->G, -597G-->A and -1363G-->T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). RESULTS: Homozygosity for the rare G allele IL-6 -572C-->G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C-->G genotype in control subjects (G/G: 2.33 +/- 0.41: C/G: 1.53 +/- 0.09: C/C: 1.72 +/- 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 +/- 2.9: C/G: 9.2 +/- 0.6: C/C: 7.8 +/- 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G-->A and -1363G-->T were monomorphic in this population. CONCLUSIONS: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 238~244 | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/epidemiology* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/ethnology* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Homozygote | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin/blood | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Interleukin-6/genetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Interleukin-6 (IL-6) -572C-->G promoter polymorphism is associated with type 2 diabetes risk in Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Soo Jeong Koh | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Yae Jung Hyun | - |
dc.contributor.googleauthor | Ju Yeon Park | - |
dc.contributor.googleauthor | Young Duk Song | - |
dc.contributor.googleauthor | Kyung-Kyun Shin | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Byung-Keuk Kim | - |
dc.contributor.googleauthor | Jose M. Ordovas | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1111/j.1365-2265.2008.03315.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00571 | - |
dc.identifier.eissn | 1365-2265 | - |
dc.identifier.pmid | 18573122 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2008.03315.x/abstract | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 70 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 238 | - |
dc.citation.endPage | 244 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, Vol.70(2) : 238-244, 2009 | - |
dc.identifier.rimsid | 37335 | - |
dc.type.rims | ART | - |
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