Cited 75 times in
H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호근 | - |
dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2015-04-24T16:23:35Z | - |
dc.date.available | 2015-04-24T16:23:35Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103430 | - |
dc.description.abstract | Ras is an important proto-protein that is regulated primarily by GDP/GTP exchange. Here, we report a novel regulatory mechanism whereby turnover of both endogenous and overexpressed H-Ras protein is controlled by beta-TrCP-mediated ubiquitylation, proteasomal degradation and the Wnt/beta-catenin signaling pathway. The interaction of H-Ras with the WD40 domain of beta-TrCP targeted H-Ras for polyubiquitylation and degradation. This process was stimulated by Axin or adenomatous polyposis coli (Apc), and was inhibited by Wnt3a. Ras-mediated cellular transformation was also inhibited by the expression of beta-TrCP and/or Axin. In vivo regulation of Ras stability by Wnt/beta-catenin signaling was determined via measurements of the status of Ras in the intestines of mice stimulated with recombinant Wnt3a by intravenous tail vein injection. The regulation of Ras stability by Wnt/beta-catenin signaling provides a mechanical basis for crosstalk between the Wnt/beta-catenin and the Ras-ERK pathways involved in transformation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 842~848 | - |
dc.relation.isPartOf | JOURNAL OF CELL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Intestines/cytology | - |
dc.subject.MESH | Intestines/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Proteasome Endopeptidase Complex/metabolism | - |
dc.subject.MESH | Protein Binding/drug effects | - |
dc.subject.MESH | Protein Processing, Post-Translational*/drug effects | - |
dc.subject.MESH | Protein Stability/drug effects | - |
dc.subject.MESH | Proto-Oncogene Proteins p21(ras)/metabolism* | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Signal Transduction*/drug effects | - |
dc.subject.MESH | Ubiquitination*/drug effects | - |
dc.subject.MESH | Up-Regulation/drug effects | - |
dc.subject.MESH | Wnt Proteins/administration & dosage | - |
dc.subject.MESH | Wnt Proteins/metabolism* | - |
dc.subject.MESH | Wnt Proteins/pharmacology | - |
dc.subject.MESH | Wnt3 Protein | - |
dc.subject.MESH | Wnt3A Protein | - |
dc.subject.MESH | beta Catenin/metabolism* | - |
dc.subject.MESH | beta-Transducin Repeat-Containing Proteins/chemistry | - |
dc.subject.MESH | beta-Transducin Repeat-Containing Proteins/metabolism* | - |
dc.title | H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Sung-Eun Kim | - |
dc.contributor.googleauthor | Ju-Yong Yoon | - |
dc.contributor.googleauthor | Woo-Jeong Jeong | - |
dc.contributor.googleauthor | Soung-Hoo Jeon | - |
dc.contributor.googleauthor | Yoon Park | - |
dc.contributor.googleauthor | Jong-Bok Yoon | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Kang-Yell Choi | - |
dc.identifier.doi | 10.1242/jcs.040493 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J01301 | - |
dc.identifier.eissn | 1477-9137 | - |
dc.identifier.pmid | 19240121 | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.citation.volume | 122 | - |
dc.citation.number | pt 6 | - |
dc.citation.startPage | 842 | - |
dc.citation.endPage | 848 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL SCIENCE, Vol.122(pt 6) : 842-848, 2009 | - |
dc.identifier.rimsid | 37334 | - |
dc.type.rims | ART | - |
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