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Signal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells

DC FieldValueLanguage
dc.contributor.author윤주헌-
dc.contributor.author윤호근-
dc.date.accessioned2015-04-24T16:22:13Z-
dc.date.available2015-04-24T16:22:13Z-
dc.date.issued2009-
dc.identifier.issn1044-1549-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103400-
dc.description.abstractMUC5B is a major mucin of the human respiratory tract, and it is not clear how MUC5B expression is regulated in various airway diseases. The goal of this study was to determine the mechanisms by which 17beta-estradiol induces MUC5B gene expression in airway epithelial cells. It was found that E2, a sex hormone, stimulates MUC5B gene overexpression by interaction with estrogen receptor alpha (ERalpha) and by acting through extracellular signal-regulated kinase 1/2 (ERK1/2)-mitogen-activated protein kinase (MAPK). Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression. It was also found that the activation of p90 ribosomal S 6 protein kinase 1 (RSK1), cAMP-response element-binding protein (CREB), and cAMP-response element (CRE) (-956 region of the MUC5B promoter)-responsive signaling cascades via ERK1/2 MAPK are crucial aspects of the intracellular mechanisms that mediate MUC5B gene expression. Taken together, these studies give additional insights into the molecular mechanism of hormone-induced MUC5B gene expression and enhance our understanding of abnormal mucin secretion in response to hormonal imbalances-
dc.description.statementOfResponsibilityopen-
dc.format.extent168~178-
dc.relation.isPartOfAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCyclic AMP Response Element-Binding Protein/genetics-
dc.subject.MESHCyclic AMP Response Element-Binding Protein/metabolism-
dc.subject.MESHEnzyme Activation/drug effects-
dc.subject.MESHEnzyme Activation/physiology-
dc.subject.MESHEpithelial Cells/cytology-
dc.subject.MESHEpithelial Cells/metabolism*-
dc.subject.MESHEstradiol/analogs & derivatives-
dc.subject.MESHEstradiol/pharmacology*-
dc.subject.MESHEstrogen Antagonists/pharmacology-
dc.subject.MESHEstrogen Receptor alpha/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation/drug effects*-
dc.subject.MESHGene Expression Regulation/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMAP Kinase Signaling System/drug effects*-
dc.subject.MESHMAP Kinase Signaling System/physiology-
dc.subject.MESHMale-
dc.subject.MESHMitogen-Activated Protein Kinase 1/metabolism-
dc.subject.MESHMitogen-Activated Protein Kinase 3/metabolism-
dc.subject.MESHMucin-5B/biosynthesis*-
dc.subject.MESHRespiratory Mucosa/cytology-
dc.subject.MESHRespiratory Mucosa/metabolism*-
dc.subject.MESHResponse Elements/physiology-
dc.subject.MESHRibosomal Protein S6 Kinases, 90-kDa/metabolism-
dc.titleSignal pathway of 17beta-estradiol-induced MUC5B expression in human airway epithelial cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorHye Joung Choi-
dc.contributor.googleauthorYoo-Sam Chung-
dc.contributor.googleauthorHyun Jik Kim-
dc.contributor.googleauthorUk Yeol Moon-
dc.contributor.googleauthorYeon Ho Choi-
dc.contributor.googleauthorIsabelle Van Seuningen-
dc.contributor.googleauthorSeung Joon Baek-
dc.contributor.googleauthorHo-Geun Yoon-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.identifier.doi10.1165/rcmb.2007-0377OC-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02604-
dc.contributor.localIdA02625-
dc.relation.journalcodeJ00113-
dc.identifier.eissn1535-4989-
dc.identifier.pmid18688042-
dc.identifier.urlhttp://www.atsjournals.org/doi/abs/10.1165/rcmb.2007-0377OC?journalCode=ajrcmb-
dc.subject.keywordMUC5B-
dc.subject.keywordestrogen-
dc.subject.keywordErα-
dc.subject.keywordCREB-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.citation.volume40-
dc.citation.number2-
dc.citation.startPage168-
dc.citation.endPage178-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol.40(2) : 168-178, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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