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In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer

Authors
 Jae-Joon Jung  ;  Hei-Cheul Jeung  ;  Hyun Cheol Chung  ;  Jung Ok Lee  ;  Tae Soo Kim  ;  Yong Tai Kim  ;  Sung Hoon Noh  ;  Sun Young Rha 
Citation
 GENOMICS, Vol.93(1) : 52-61, 2009 
Journal Title
 GENOMICS 
ISSN
 0888-7543 
Issue Date
2009
MeSH
Antineoplastic Agents/pharmacology* ; Cell Line, Tumor ; Databases, Genetic ; Drug Resistance, Neoplasm ; Gene Expression Profiling* ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism* ; Oligonucleotide Array Sequence Analysis ; Predictive Value of Tests ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics*
Keywords
Pharmacogenomic database ; Chemotherapy ; Predictive marker ; Gastric cancer
Abstract
Gastric cancer is one of the most common cancers worldwide, and there are clinical caveats in predicting tumor response to chemotherapy. This study describes the construction of an in vitro pharmacogenomic database, and the selection of genes associated with chemosensitivity in gastric cancer cell lines. Gene expression and chemosensitivity databases were integrated using the Pearson correlation coefficient to give the GC-matrix. The 85 genes were selected that were commonly associated with chemosensitivity of the major anticancer drugs. We then focused on the genes that were highly correlated with each specific drug. Classification of cell lines based on the set of genes associated with each drug was consistent with the division into resistant or sensitive groups according to the chemosensitivity results. The GC-matrix of the gastric cancer cell line database was used to identify different sets of chemosensitivity-related genes for specific drugs or multiple drugs.
Full Text
http://www.sciencedirect.com/science/article/pii/S0888754308001869
DOI
10.1016/j.ygeno.2008.08.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Yong Tai(김용태)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Lee, Jung Ok(이정옥)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103375
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