1 264

Cited 30 times in

Oxyntic atrophy, metaplasia, and gastric cancer

Authors
 James R. Goldenring  ;  Ki Taek Nam 
Citation
 PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE, Vol.96 : 117-131, 2010 
Journal Title
 PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE 
ISSN
 1877-1173 
Issue Date
2010
MeSH
Animals ; Atrophy ; Biomarkers, Tumor/metabolism ; Gastric Mucosa/pathology ; Humans ; Metaplasia ; Parietal Cells, Gastric/pathology* ; Stomach Neoplasms/pathology*
Abstract
Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent replacement of the normal gastric lineages with metaplastic cells. In humans, two metaplastic lineages develop as sequelae of chronic Helicobacter pylori infection: intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM). Mouse models of both chronic Helicobacter infection and acute pharmacological oxyntic atrophy have led to the discovery that SPEM arises from transdifferentiation of mature chief cells. The presence of inflammation promotes the expansion of SPEM in mice. Furthermore, studies in Mongolian gerbils as well as increasing evidence from human studies indicate that SPEM likely represents a precursor for the development of intestinal metaplasia. These findings suggest that loss of parietal cells, augmented by chronic inflammation, leads to a cascade of metaplastic events. Identification of specific biomarkers for SPEM and intestinal metaplasia hold promise for providing both early detection of preneoplasia and information on prognostic outcome following curative resection.
Full Text
http://www.sciencedirect.com/science/article/pii/B9780123812803000051
DOI
10.1016/B978-0-12-381280-3.00005-1
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103282
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links