2 173

Cited 38 times in

Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague

DC FieldValueLanguage
dc.contributor.author박채규-
dc.date.accessioned2015-04-23T17:51:32Z-
dc.date.available2015-04-23T17:51:32Z-
dc.date.issued2010-
dc.identifier.issn0014-2980-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103270-
dc.description.abstractTo help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α(+) DEC-205(+) or CD8α(-) DCIR2(+) DC along with a clinically feasible adjuvant, poly IC. By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC-targeted LcrV induced polarized Th1 immunity, whereas DCIR2-targeted LcrV induced fewer CD4(+) T cells secreting IFN-γ, but higher IL-4, IL-5, IL-10, and IL-13 production. DCIR-2 targeting elicited higher anti-LcrV Ab titers than DEC targeting, which were comparable to a protein vaccine given in alhydrogel adjuvant, but the latter did not induce detectable T-cell immunity. When DEC- and DCIR2-targeted and F1-V+ alhydrogel-vaccinated mice were challenged 6 wk after vaccination with the virulent CO92 Y. pestis, the protection level and Ab titers induced by DCIR2 targeting were similar to those induced by F1-V protein with alhydrogel vaccination. Therefore, LcrV targeting to DC elicits combined humoral and cellular immunity, and for the first time with this approach, also induces protection in a mouse model for a human pathogen-
dc.description.statementOfResponsibilityopen-
dc.format.extent2791~2796-
dc.relation.isPartOfEUROPEAN JOURNAL OF IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdjuvants, Immunologic/pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Bacterial/blood-
dc.subject.MESHAntigens, Bacterial/immunology*-
dc.subject.MESHCytokines/blood-
dc.subject.MESHImmunity, Cellular/immunology-
dc.subject.MESHImmunity, Humoral/immunology-
dc.subject.MESHImmunization/methods*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHPlague/immunology-
dc.subject.MESHPlague/microbiology*-
dc.subject.MESHPlague/prevention & control*-
dc.subject.MESHPlague Vaccine/immunology-
dc.subject.MESHPore Forming Cytotoxic Proteins/immunology*-
dc.subject.MESHSpecific Pathogen-Free Organisms-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHVaccines, Synthetic/immunology-
dc.subject.MESHVirulence-
dc.subject.MESHYersinia pestis/immunology*-
dc.subject.MESHYersinia pestis/pathogenicity*-
dc.titleTargeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorYoonkyung Do-
dc.contributor.googleauthorHyein Koh-
dc.contributor.googleauthorChae Gyu Park-
dc.contributor.googleauthorDiana Dudziak-
dc.contributor.googleauthorPatrick Seo-
dc.contributor.googleauthorS. Mehandru-
dc.contributor.googleauthorJae-Hoon Choi-
dc.contributor.googleauthorCheolho Cheong-
dc.contributor.googleauthorSteven Park-
dc.contributor.googleauthorDavid S. Perlin-
dc.contributor.googleauthorBradford S. Powell-
dc.contributor.googleauthorRalph M. Steinman-
dc.identifier.doi10.1002/eji.201040511-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01718-
dc.relation.journalcodeJ00825-
dc.identifier.eissn1521-4141-
dc.identifier.pmid20812236-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/eji.201040511/abstract-
dc.contributor.alternativeNamePark, Chae Gyu-
dc.contributor.affiliatedAuthorPark, Chae Gyu-
dc.citation.volume40-
dc.citation.number10-
dc.citation.startPage2791-
dc.citation.endPage2796-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF IMMUNOLOGY, Vol.40(10) : 2791-2796, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.