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Sildenafil and beraprost combination therapy in patients with pulmonary hypertension undergoing valvular heart surgery

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author김소연-
dc.contributor.author심연희-
dc.contributor.author심재광-
dc.date.accessioned2015-04-23T17:51:00Z-
dc.date.available2015-04-23T17:51:00Z-
dc.date.issued2010-
dc.identifier.issn0966-8519-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103253-
dc.description.abstractBACKGROUND AND AIM OF THE STUDY: Sildenafil and beraprost, as orally available pulmonary vasodilators, are used increasingly to treat pulmonary hypertension (PH). An evaluation was made, in patients with PH undergoing valvular heart surgery, as to whether preoperative combined oral sildenafil and beraprost treatment could induce synergistic and prolonged pulmonary vasodilation, or result in a loss of pulmonary selectivity. METHODS: Fifty patients scheduled for valvular heart surgery with a mean pulmonary arterial pressure (PAP) > 30 mmHg were randomly assigned to receive either 50 mg oral sildenafil + 40 microg beraprost, or a placebo, 15 min before the induction of anesthesia. Hemodynamic variables were measured intraoperatively. RESULTS: The treatment group had a significantly lower systemic vascular resistance index at 60 min after medication. No other significant intergroup differences in hemodynamic variables were observed. In addition, significantly more patients in the treatment group required vasopressor therapy. In both groups, the PAP was significantly reduced by general anesthesia, and almost normalized after valvular heart surgery. CONCLUSION: Preoperative oral sildenafil and beraprost treatment resulted in a loss of pulmonary selectivity, and did not provide any additional pulmonary vasodilation or favorable perioperative hemodynamics in patients with PH undergoing valvular heart surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent333~340-
dc.relation.isPartOfJOURNAL OF HEART VALVE DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnesthesia, General-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHComorbidity-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHEpoprostenol/administration & dosage-
dc.subject.MESHEpoprostenol/analogs & derivatives*-
dc.subject.MESHEpoprostenol/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases/epidemiology*-
dc.subject.MESHHeart Valve Diseases/surgery*-
dc.subject.MESHHemodynamics-
dc.subject.MESHHumans-
dc.subject.MESHHypertension, Pulmonary/drug therapy*-
dc.subject.MESHHypertension, Pulmonary/epidemiology-
dc.subject.MESHHypertension, Pulmonary/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPiperazines/administration & dosage-
dc.subject.MESHPiperazines/therapeutic use*-
dc.subject.MESHPreoperative Care-
dc.subject.MESHPurines/administration & dosage-
dc.subject.MESHPurines/therapeutic use-
dc.subject.MESHSildenafil Citrate-
dc.subject.MESHSulfones/administration & dosage-
dc.subject.MESHSulfones/therapeutic use*-
dc.subject.MESHVascular Resistance/drug effects-
dc.subject.MESHVasoconstrictor Agents/therapeutic use-
dc.subject.MESHVasodilator Agents/administration & dosage-
dc.subject.MESHVasodilator Agents/therapeutic use*-
dc.titleSildenafil and beraprost combination therapy in patients with pulmonary hypertension undergoing valvular heart surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorJae Kwang Shim-
dc.contributor.googleauthorYeon Hee Shim-
dc.contributor.googleauthorSeong Wook Hong-
dc.contributor.googleauthorKil Hwan Choi-
dc.contributor.googleauthorYoung Lan Kwak-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02196-
dc.contributor.localIdA02205-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ01437-
dc.identifier.eissn2053-2644-
dc.identifier.pmid20583396-
dc.identifier.urlhttp://www.icr-heart.com/?cid=2253-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameShim, Yon Hee-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorShim, Yon Hee-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage333-
dc.citation.endPage340-
dc.identifier.bibliographicCitationJOURNAL OF HEART VALVE DISEASE, Vol.19(3) : 333-340, 2010-
dc.identifier.rimsid37225-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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