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CIIA is a novel regulator of detachment-induced cell death.

Authors
 Kwang Je Kim  ;  Je-Wook Yu  ;  Hyun Sub Hwang  ;  Eui-Ju Choi 
Citation
 CANCER RESEARCH, Vol.70(15) : 6352-6358, 2010 
Journal Title
CANCER RESEARCH
ISSN
 0008-5472 
Issue Date
2010
MeSH
Animals ; Anoikis/physiology* ; Apoptosis Regulatory Proteins/biosynthesis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/physiology* ; Caspase 9/metabolism ; Cell Adhesion/physiology ; Cell Growth Processes/physiology ; Cell Line ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology* ; Dogs ; Enzyme Activation ; Gene Knockdown Techniques ; Humans ; Transfection ; Up-Regulation
Abstract
Detachment-induced cell death, or anoikis, is a type of apoptosis that occurs when epithelial cells lose their attachment to the extracellular matrix. Anoikis serves as a physiologic barrier to metastasis. Deviation from the tightly regulated mechanism of detachment-induced cell death might result in progression to metastatic cancer. Here, we investigated the function of CIIA in the regulation of anoikis. CIIA protein was upregulated in colon cancer tissue samples. Knockdown of CIIA in metastatic colorectal carcinoma SW620 and KM12SM cells promoted detachment-induced cell death through the regulation of caspase activation. Knockdown of CIIA also inhibited anchorage-independent growth in soft agar and colony formation after suspension stress. These observations suggest that CIIA is a novel negative regulator of anoikis.
Files in This Item:
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DOI
10.1158/0008-5472.CAN-09-4394
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yu, Je Wook(유제욱) ORCID logo https://orcid.org/0000-0001-5943-4071
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103243
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