Cited 28 times in
The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 김준원 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 안중배 | - |
dc.date.accessioned | 2015-04-23T17:50:15Z | - |
dc.date.available | 2015-04-23T17:50:15Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103229 | - |
dc.description.abstract | BACKGROUND: Synchronous liver metastases are detected in approximately 25% of colorectal cancer patients at diagnosis. The rates of local failure and distant metastasis are substantial in these patients, even after undergoing aggressive treatments including resection of primary and metastatic liver tumors. The purpose of this study was to determine whether adjuvant pelvic radiotherapy is beneficial for pelvic control and overall survival in rectal cancer patients with synchronous liver metastasis after primary tumor resection. METHODS: Among rectal cancer patients who received total mesorectal excision (TME) between 1997 and 2006 at Yonsei University Health System, eighty-nine patients diagnosed with synchronous liver metastasis were reviewed. Twenty-seven patients received adjuvant pelvic RT (group S + R), and sixty-two patients were managed without RT (group S). Thirty-six patients (58%) in group S and twenty patients (74%) in group S+R received local treatment for liver metastasis. Failure patterns and survival outcomes were analyzed. RESULTS: Pelvic failure was observed in twenty-five patients; twenty-one patients in group S (34%), and four patients in group S+R (15%) (p = 0.066). The two-year pelvic failure-free survival rates (PFFS) of group S and group S+R were 64.8% and 80.8% (p = 0.028), respectively, and the two-year overall survival rates (OS) were 49.1% and 70.4% (p = 0.116), respectively. In a subgroup analysis of fifty-six patients who received local treatment for liver metastasis, the two-year PFFS were 64.9% and 82.9% (p = 0.05), respectively; the two-year OS were 74.1% and 80.0% (p = 0.616) in group S (n = 36) and group S+R (n = 20), respectively. CONCLUSIONS: Adjuvant pelvic RT significantly reduced the pelvic failure rate but its influence on overall survival was unclear. Rectal cancer patients with synchronous liver metastasis may benefit from adjuvant pelvic RT through an increased pelvic control rate and improved quality of life | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 75 | - |
dc.relation.isPartOf | RADIATION ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/radiotherapy* | - |
dc.subject.MESH | Adenocarcinoma/secondary | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Digestive System Surgical Procedures | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Liver Neoplasms/radiotherapy* | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Pelvis | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Rectal Neoplasms/pathology | - |
dc.subject.MESH | Rectal Neoplasms/radiotherapy* | - |
dc.subject.MESH | Rectal Neoplasms/surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Nam-Kyu Kim | - |
dc.contributor.googleauthor | Byung-Soh Min | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.1186/1748-717X-5-75 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A00744 | - |
dc.relation.journalcode | J02591 | - |
dc.identifier.eissn | 1748-717X | - |
dc.identifier.pmid | 20804559 | - |
dc.subject.keyword | Rectal Cancer | - |
dc.subject.keyword | Liver Metastasis | - |
dc.subject.keyword | Rectal Cancer Patient | - |
dc.subject.keyword | Primary Tumor Resection | - |
dc.subject.keyword | Metastatic Liver Tumor | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Joong Bae | - |
dc.contributor.affiliatedAuthor | Kim, Yong Bae | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 75 | - |
dc.identifier.bibliographicCitation | RADIATION ONCOLOGY, Vol.5 : 75, 2010 | - |
dc.identifier.rimsid | 37204 | - |
dc.type.rims | ART | - |
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