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Regulation of tumor angiogenesis by EZH2

DC FieldValueLanguage
dc.contributor.author임재윤-
dc.date.accessioned2015-04-23T17:49:39Z-
dc.date.available2015-04-23T17:49:39Z-
dc.date.issued2010-
dc.identifier.issn1535-6108-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103209-
dc.description.abstractAlthough VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in endothelial EZH2 is a direct result of VEGF stimulation by a paracrine circuit that promotes angiogenesis by methylating and silencing vasohibin1 (vash1). Ezh2 silencing in the tumor-associated endothelial cells inhibited angiogenesis mediated by reactivation of VASH1, and reduced ovarian cancer growth, which is further enhanced in combination with ezh2 silencing in tumor cells. Collectively, these data support the potential for targeting ezh2 as an important therapeutic approach.-
dc.description.statementOfResponsibilityopen-
dc.format.extent185~197-
dc.relation.isPartOfCANCER CELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation-
dc.subject.MESHDNA Methylation-
dc.subject.MESHDNA Primers-
dc.subject.MESHEnhancer of Zeste Homolog 2 Protein-
dc.subject.MESHFemale-
dc.subject.MESHGene Silencing-
dc.subject.MESHHistone-Lysine N-Methyltransferase/genetics-
dc.subject.MESHHistone-Lysine N-Methyltransferase/physiology*-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMicroscopy, Fluorescence-
dc.subject.MESHNeovascularization, Pathologic/physiopathology*-
dc.subject.MESHOvarian Neoplasms/blood supply*-
dc.subject.MESHOvarian Neoplasms/pathology-
dc.subject.MESHPolycomb Repressive Complex 2-
dc.titleRegulation of tumor angiogenesis by EZH2-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChunhua Lu-
dc.contributor.googleauthorHee Dong Han-
dc.contributor.googleauthorLingegowda S. Mangala-
dc.contributor.googleauthorRouba Ali-Fehmi-
dc.contributor.googleauthorChristopher S. Newton-
dc.contributor.googleauthorLaurent Ozbun-
dc.contributor.googleauthorGuillermo N. Armaiz-Pena-
dc.contributor.googleauthorWei Hu-
dc.contributor.googleauthorRebecca L. Stone-
dc.contributor.googleauthorAdnan Munkarah-
dc.contributor.googleauthorMurali K. Ravoori-
dc.contributor.googleauthorMian M. K. Shahzad-
dc.contributor.googleauthorJeong-Won Lee-
dc.contributor.googleauthorEdna Mora-
dc.contributor.googleauthorRobert R. Langley-
dc.contributor.googleauthorAmy R. Carroll-
dc.contributor.googleauthorKoji Matsuo-
dc.contributor.googleauthorWhitney A. Spannuth-
dc.contributor.googleauthorRosemarie Schmandt-
dc.contributor.googleauthorNicholas B. Jennings-
dc.contributor.googleauthorBlake W. Goodman-
dc.contributor.googleauthorRobert B. Jaffe-
dc.contributor.googleauthorAlpa M. Nick-
dc.contributor.googleauthorHye Sun Kim-
dc.contributor.googleauthorEylem Ozturk Guven-
dc.contributor.googleauthorYa-Huey Chen-
dc.contributor.googleauthorLong-Yuan Li-
dc.contributor.googleauthorMing-Chuan Hsu-
dc.contributor.googleauthorRobert L. Coleman-
dc.contributor.googleauthorGeorge A. Calin-
dc.contributor.googleauthorEmir B. Denkbas-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorJu-Seog Lee-
dc.contributor.googleauthorVikas Kundra-
dc.contributor.googleauthorMichael J. Birrer-
dc.contributor.googleauthorMien-Chie Hung-
dc.contributor.googleauthorGabriel Lopez-Berestein-
dc.contributor.googleauthorAnil K. Sood-
dc.identifier.doi10.1016/j.ccr.2010.06.016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03398-
dc.relation.journalcodeJ03124-
dc.identifier.eissn1878-3686-
dc.identifier.pmid20708159-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.citation.volume18-
dc.citation.number2-
dc.citation.startPage185-
dc.citation.endPage197-
dc.identifier.bibliographicCitationCANCER CELL, Vol.18(2) : 185-197, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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