Cited 9 times in
A promoter polymorphism -2122C>T of CHI3L1 is associated with serum low density lipoprotein cholesterol level in Korean subjects
DC Field | Value | Language |
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dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-04-23T17:49:08Z | - |
dc.date.available | 2015-04-23T17:49:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103193 | - |
dc.description.abstract | OBJECTIVES: This study assessed the effects of 10 tagging single nucleotide polymorphisms (SNPs) of the CHI3L1 gene on serum LDL cholesterol levels in 290 Korean subjects. DESIGN AND METHODS: Genotyping analyses of SNPs were conducted by TaqMan® method. The effects of the promoter SNP on mRNA expression and nuclear factor binding were measured by real-time PCR and electrophoretic mobility shift assay, respectively. RESULTS: Among 10 tagging SNPs, -2122C>T SNP (rs946261) in the promoter region was significantly associated with serum LDL cholesterol level (P=0.005). The T allele of -2122C>T was associated with significantly increased mRNA expressions in peripheral blood cells of the subjects, and also increased a nuclear factor binding measured by an electrophoretic mobility shift assay. CONCLUSIONS: -2122C>T of CHI3L1, a promoter SNP which affects the mRNA expression and nuclear factor binding, is significantly associated with serum LDL cholesterol levels in Korean subjects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1195~1200 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipokines | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Base Pairing/genetics | - |
dc.subject.MESH | Chitinase-3-Like Protein 1 | - |
dc.subject.MESH | Cholesterol, LDL/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glycoproteins/genetics* | - |
dc.subject.MESH | Glycoproteins/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lectins/genetics* | - |
dc.subject.MESH | Lectins/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolome/genetics | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nuclear Proteins/metabolism | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | A promoter polymorphism -2122C>T of CHI3L1 is associated with serum low density lipoprotein cholesterol level in Korean subjects | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Haeyong Lee | - |
dc.contributor.googleauthor | Ryunhwa Kang | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Yoosik Yoon | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2010.07.017 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00561 | - |
dc.identifier.eissn | 1873-2933 | - |
dc.identifier.pmid | 20674561 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009912010003322 | - |
dc.subject.keyword | CHI3L1 | - |
dc.subject.keyword | Promoter | - |
dc.subject.keyword | SNP | - |
dc.subject.keyword | rs946261 | - |
dc.subject.keyword | LDL cholesterol | - |
dc.subject.keyword | EMSA | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.citation.volume | 43 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1195 | - |
dc.citation.endPage | 1200 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, Vol.43(15) : 1195-1200, 2010 | - |
dc.identifier.rimsid | 35753 | - |
dc.type.rims | ART | - |
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