Cited 0 times in
CDH1 유전자 다형성 -160C>A와 대장결장암 발생에 관한 정량적 메타분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 설재웅 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2015-04-23T17:49:03Z | - |
dc.date.available | 2015-04-23T17:49:03Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1226-9476 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103190 | - |
dc.description.abstract | Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene-160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data. Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer. Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1-160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p=0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p=0.001). Similarly, from 2 studies for CDH1-347G>A (rs5030625) in relation to colorectal cancer was 1.331 (1.029, 1.722; p=0.029). Conclusion: Our findings support that CDH1-160C>A is significantly associated with colorectal cancer risk. Further studies are needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~15 | - |
dc.relation.isPartOf | Journal of the Korea Society of Health Informatics and Statistics (한국보건정보통계학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | CDH1 유전자 다형성 -160C>A와 대장결장암 발생에 관한 정량적 메타분석 | - |
dc.title.alternative | Cadherin-1 (CDH1) polymorphism and the risk of colorectal cancer: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | 조재승 | - |
dc.contributor.googleauthor | 유미경 | - |
dc.contributor.googleauthor | 박은정 | - |
dc.contributor.googleauthor | 설재웅 | - |
dc.contributor.googleauthor | 지선하 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01942 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J03183 | - |
dc.subject.keyword | Gene | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | Cadherin-1 | - |
dc.subject.keyword | meta-analysis | - |
dc.contributor.alternativeName | Sull, Jae Woong | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Sull, Jae Woong | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.identifier.bibliographicCitation | Journal of the Korea Society of Health Informatics and Statistics (한국보건정보통계학회지), Vol.35(1) : 1-15, 2010 | - |
dc.identifier.rimsid | 35751 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.