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CDH1 유전자 다형성 -160C>A와 대장결장암 발생에 관한 정량적 메타분석

Other Titles
 Cadherin-1 (CDH1) polymorphism and the risk of colorectal cancer: A meta-analysis 
Authors
 조재승  ;  유미경  ;  박은정  ;  설재웅  ;  지선하 
Citation
 Journal of the Korea Society of Health Informatics and Statistics (한국보건정보통계학회지), Vol.35(1) : 1-15, 2010 
Journal Title
Journal of the Korea Society of Health Informatics and Statistics(한국보건정보통계학회지)
ISSN
 1226-9476 
Issue Date
2010
Keywords
Gene ; Colorectal cancer ; Cadherin-1 ; meta-analysis
Abstract
Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene-160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data. Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer. Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1-160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p=0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p=0.001). Similarly, from 2 studies for CDH1-347G>A (rs5030625) in relation to colorectal cancer was 1.331 (1.029, 1.722; p=0.029). Conclusion: Our findings support that CDH1-160C>A is significantly associated with colorectal cancer risk. Further studies are needed.
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Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Sull, Jae Woong(설재웅)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103190
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