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Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver.

DC FieldValueLanguage
dc.contributor.author김경섭-
dc.contributor.author김미영-
dc.contributor.author김태현-
dc.contributor.author박주만-
dc.contributor.author배진식-
dc.contributor.author안용호-
dc.date.accessioned2015-04-23T17:48:59Z-
dc.date.available2015-04-23T17:48:59Z-
dc.date.issued2010-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103188-
dc.description.abstractDuring a state of fasting, the blood glucose level is maintained by hepatic gluconeogenesis. SIRT1 is an important metabolic regulator during nutrient deprivation and the liver-specific knockdown of SIRT1 resulted in decreased glucose production. We hypothesize that SIRT1 is responsible for the upregulation of insulin-suppressed gluconeogenic genes through the deacetylation of FOXO1. Treatment of primary cultured hepatocytes with resveratrol increased insulin-repressed PEPCK and G6Pase mRNA levels, which depend on SIRT1 activity. We found that the resveratrol treatment resulted in a decrease in the phosphorylation of Akt and FOXO1, which are independent of SIRT1 action. Fluorescence microscopy revealed that resveratrol caused the nuclear localization of FOXO1. In the nucleus, FOXO1 is deacetylated by SIRT1, which might make it more accessible to the IRE of the PEPCK and G6Pase promoter, causing an increase in their gene expression. Our results indicate that resveratrol upregulates the expression of gluconeogenic genes by attenuating insulin signaling and by deacetylating FOXO1, which are SIRT1-independent in the cytosol and SIRT1-dependent in the nucleus, respectively.-
dc.description.statementOfResponsibilityopen-
dc.format.extent329~334-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/pharmacology*-
dc.subject.MESHForkhead Box Protein O1-
dc.subject.MESHForkhead Transcription Factors/genetics-
dc.subject.MESHForkhead Transcription Factors/metabolism*-
dc.subject.MESHGene Expression/drug effects*-
dc.subject.MESHGluconeogenesis/drug effects*-
dc.subject.MESHGluconeogenesis/genetics-
dc.subject.MESHHumans-
dc.subject.MESHLiver/drug effects*-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHPhosphorylation-
dc.subject.MESHRNA, Small Interfering/genetics-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSirtuin 1/genetics-
dc.subject.MESHSirtuin 1/metabolism-
dc.subject.MESHStilbenes/pharmacology*-
dc.subject.MESHUp-Regulation-
dc.titleRole of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorJoo-Man Park-
dc.contributor.googleauthorTae-Hyun Kim-
dc.contributor.googleauthorJin-Sik Bae-
dc.contributor.googleauthorMi-Young Kim-
dc.contributor.googleauthorKyung-Sup Kim-
dc.contributor.googleauthorYong-Ho Ahn-
dc.identifier.doi10.1016/j.bbrc.2010.11.028-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00297-
dc.contributor.localIdA00446-
dc.contributor.localIdA01666-
dc.contributor.localIdA01809-
dc.contributor.localIdA02249-
dc.contributor.localIdA01081-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid21078299-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X10020760-
dc.subject.keywordResveratrol-
dc.subject.keywordFOXO1-
dc.subject.keywordSIRT1-
dc.subject.keywordGluconeogenesis-
dc.contributor.alternativeNameKim, Kyung Sup-
dc.contributor.alternativeNameKim, Mi Young-
dc.contributor.alternativeNameKim, Tae Hyun-
dc.contributor.alternativeNamePark, Joo Man-
dc.contributor.alternativeNameBae, Jin Sik-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Kyung Sup-
dc.contributor.affiliatedAuthorKim, Mi Young-
dc.contributor.affiliatedAuthorPark, Joo Man-
dc.contributor.affiliatedAuthorBae, Jin Sik-
dc.contributor.affiliatedAuthorAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Tae Hyun-
dc.citation.volume403-
dc.citation.number3-4-
dc.citation.startPage329-
dc.citation.endPage334-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.403(3-4) : 329-334, 2010-
dc.identifier.rimsid35749-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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