Cited 13 times in
A mammalian insulysin homolog is regulated by enzyme IIA(Glc) of the glucose transport system in Vibrio vulnificus.
DC Field | Value | Language |
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dc.contributor.author | 박순정 | - |
dc.date.accessioned | 2015-04-23T17:48:08Z | - |
dc.date.available | 2015-04-23T17:48:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103160 | - |
dc.description.abstract | Vibrio vulnificus is an opportunistic human pathogen that causes severe infections in susceptible individuals. While the components of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system (PTS) have been shown to regulate numerous targets, little such information is available for the V. vulnificus PTS. Here we show that enzyme IIA(Glc) of the PTS regulates the peptidase activity of a mammalian insulysin homolog in V. vulnificus. While interaction of IIA(Glc) with the insulysin homolog is independent of the phosphorylation state of IIA(Glc), only unphosphorylated IIA(Glc) activates the insulysin homolog. Taken together, our results suggest that the V. vulnificus insulysin-IIA(Glc) complex plays a role in survival in the host by sensing glucose. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4537~4544 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biological Transport | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulysin/chemistry* | - |
dc.subject.MESH | Insulysin/metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Sequence Homology, Amino Acid* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Vibrio vulnificus/enzymology* | - |
dc.subject.MESH | Vibrio vulnificus/metabolism | - |
dc.subject.MESH | Vibrio vulnificus/pathogenicity | - |
dc.title | A mammalian insulysin homolog is regulated by enzyme IIA(Glc) of the glucose transport system in Vibrio vulnificus. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | You-Jin Kim | - |
dc.contributor.googleauthor | Yangkyun Ryu | - |
dc.contributor.googleauthor | Byoung-Mo Koo | - |
dc.contributor.googleauthor | Na Yeon Lee | - |
dc.contributor.googleauthor | Se-Jin Chun | - |
dc.contributor.googleauthor | Soon-Jung Park | - |
dc.contributor.googleauthor | Kyu-Ho Lee | - |
dc.contributor.googleauthor | Yeong-Jae Seok | - |
dc.identifier.doi | 10.1016/j.febslet.2010.10.035 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01545 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 20971110 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0014579310008483 | - |
dc.subject.keyword | Enzyme IIAGlc | - |
dc.subject.keyword | Insulysin | - |
dc.subject.keyword | Phosphoenolpyruvate:sugar phospho-transferase system | - |
dc.subject.keyword | Protein–protein interaction | - |
dc.subject.keyword | Vibrio vulnificus | - |
dc.contributor.alternativeName | Park, Soon Jung | - |
dc.contributor.affiliatedAuthor | Park, Soon Jung | - |
dc.citation.volume | 584 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 4537 | - |
dc.citation.endPage | 4544 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.584(22) : 4537-4544, 2010 | - |
dc.identifier.rimsid | 35732 | - |
dc.type.rims | ART | - |
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