Cited 6 times in
Cytogenetic features of 5q deletion and 5q- syndrome in myelodysplastic syndrome in Korea; marker chromosomes proved to be chromosome 5 with interstitial deletion by fluorescence in situ hybridization
DC Field | Value | Language |
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dc.contributor.author | 민유홍 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2015-04-23T17:46:55Z | - |
dc.date.available | 2015-04-23T17:46:55Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103120 | - |
dc.description.abstract | We characterized the cytogenetic changes and prognostic characteristics of 133 Korean patients with myelodysplastic syndrome (MDS), focusing on 5q- syndrome and MDS with chromosome abnormalities involving 5q deletion according to World Health Organization 2008 classification. In all patients, G banding and fluorescence in situ hybridization for 5q were performed, and in MDS patients with 5q deletion, the deleted region on chromosome 5 was mapped with fluorescence in situ hybridization for EGR1, CSF1R, and PDGFRB. The frequency of isolated del(5q) syndrome and 5q deletion was 2.2% (3 of 137 patients) and 15.3% (21 of 137 patients), respectively. International Prognostic Scoring System (IPSS) groups were low risk (5.8%), intermediate 1 (51.1%), intermediate 2 (27.8%), and high risk (15.3%). The patients with del(5q) were significantly older (62 years) and showed an unfavorable survival compared to patients without del(5q). Half (53%) of the patients with del(5q) also had complex chromosome abnormalities, including chromosome 7 abnormalities. Of the patients with del(5q), 93.3% were deleted for all three regions on 5q, compared to 66.7% of patients with isolated del(5q). Marker chromosomes proved to be chromosome 5 with interstitial deletion of q arm by fluorescence in situ hybridization in three patients. The biological characteristics of MDS in Korea seem to be markedly different from those of Caucasians, with Koreans having a younger age, lower frequencies of 5q- syndrome, higher frequencies of complex cytogenetic abnormalities including del(5q), and poorer prognosis. We infer that additional chromosome abnormalities contribute to the adverse prognostic impact in patients with del(5q). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 193~202 | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Chromosome Deletion* | - |
dc.subject.MESH | Chromosome Mapping | - |
dc.subject.MESH | Chromosomes/ultrastructure* | - |
dc.subject.MESH | Chromosomes, Human, Pair 5* | - |
dc.subject.MESH | Cytogenetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Markers* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence/methods* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | L-Selectin/metabolism | - |
dc.subject.MESH | Leukocytes, Mononuclear/cytology | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myelodysplastic Syndromes/ethnology | - |
dc.subject.MESH | Myelodysplastic Syndromes/genetics* | - |
dc.subject.MESH | T-Lymphocytes/cytology | - |
dc.title | Cytogenetic features of 5q deletion and 5q- syndrome in myelodysplastic syndrome in Korea; marker chromosomes proved to be chromosome 5 with interstitial deletion by fluorescence in situ hybridization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hye Ryun Lee | - |
dc.contributor.googleauthor | Bora Oh | - |
dc.contributor.googleauthor | Dae Sik Hong | - |
dc.contributor.googleauthor | Dae Young Zang | - |
dc.contributor.googleauthor | Hwi-Joong Yoon | - |
dc.contributor.googleauthor | Hyeoung Joon Kim | - |
dc.contributor.googleauthor | Inho Kim | - |
dc.contributor.googleauthor | Jae-Sook Ahn | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.contributor.googleauthor | Kyung Sam Cho | - |
dc.contributor.googleauthor | Mark Hong Lee | - |
dc.contributor.googleauthor | Soo-Mee Bang | - |
dc.contributor.googleauthor | Tae Young Kim | - |
dc.contributor.googleauthor | Yeo-Min Yun | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | You Kyoung Lee | - |
dc.contributor.googleauthor | Dong Soon Lee | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2010.08.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 21156233 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460810004498 | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.citation.volume | 203 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 202 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.203(2) : 193-202, 2010 | - |
dc.identifier.rimsid | 35702 | - |
dc.type.rims | ART | - |
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