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Class III beta-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders.

DC FieldValueLanguage
dc.contributor.author윤선옥-
dc.date.accessioned2015-04-23T17:46:40Z-
dc.date.available2015-04-23T17:46:40Z-
dc.date.issued2010-
dc.identifier.issn0147-5185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103112-
dc.description.abstractClass III beta-tubulin (TUBB3) expression in carcinoma is associated with resistance to tubulin-binding chemotherapeutic agents. Recently, follicular dendritic cells (FDCs) were reported to express TUBB3 under physiologic conditions. We investigated TUBB3 expression in a wide range of lymphoproliferative disorders using immunohistochemistry. Dual immunostaining for Bcl-6 and TUBB3 revealed that some germinal center B cells also express TUBB3 in addition to FDCs. In Hodgkin lymphomas (HLs), 47.1% (40/85) expressed TUBB3 in the tumor cells with an all-or-none pattern. TUBB3 expression in HL was more common in mixed cellularity type than nodular sclerosis type (P=0.032). Among non-HLs, 79.3% (23/29) of anaplastic large cell lymphoma (ALCL), 8% (2/25) of extranodal natural killer/T-cell lymphoma, and 75% (21/28) of Burkitt lymphoma showed TUBB3 expression with an all-or-none pattern. Of diffuse large B-cell lymphoma, 15.2% (32/210) expressed TUBB3 in a heterogeneous pattern. In ALCL, TUBB3 expression was more common in systemic ALCL than in primary cutaneous ALCL (P=0.046). Diffuse large B-cell lymphomas with a germinal center B-like subgroup exhibited TUBB3 expression more frequently than non-GCB-like subgroup (P=0.01). Otherwise, none of the 18 angioimmunoblastic T-cell lymphomas; 18 peripheral T-cell lymphomas, not otherwise specified; 12 follicular lymphomas; 62 marginal zone lymphomas; 7 mantle cell lymphomas; 8 small lymphocytic lymphomas; or 2 FDC sarcomas expressed TUBB3. In angioimmunoblastic T-cell lymphoma and Castleman disease, TUBB3 was positive in immunoblasts corresponding to Epstein-Barr virus-infected or Kaposi sarcoma herpes virus-infected cells. A variety of neoplastic and non-neoplastic lymphoproliferative disorders exhibited characteristic TUBB3 expression patterns; these results suggest potential for diagnostic utility, some insight into the pathobiology of TUBB3 expression, and potential therapeutic implications-
dc.description.statementOfResponsibilityopen-
dc.format.extent645~655-
dc.relation.isPartOfAmerican Journal of Surgical Pathology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCastleman Disease/metabolism-
dc.subject.MESHCastleman Disease/pathology-
dc.subject.MESHDNA-Binding Proteins/metabolism-
dc.subject.MESHDendritic Cells, Follicular/metabolism-
dc.subject.MESHDendritic Cells, Follicular/pathology-
dc.subject.MESHEpstein-Barr Virus Infections/metabolism-
dc.subject.MESHEpstein-Barr Virus Infections/pathology-
dc.subject.MESHGerminal Center/metabolism-
dc.subject.MESHGerminal Center/pathology-
dc.subject.MESHHodgkin Disease/metabolism-
dc.subject.MESHHodgkin Disease/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunoblastic Lymphadenopathy/metabolism-
dc.subject.MESHImmunoblastic Lymphadenopathy/pathology-
dc.subject.MESHLymphoma, Non-Hodgkin/metabolism-
dc.subject.MESHLymphoma, Non-Hodgkin/pathology-
dc.subject.MESHLymphoma, T-Cell/metabolism-
dc.subject.MESHLymphoma, T-Cell/pathology-
dc.subject.MESHLymphoproliferative Disorders/metabolism-
dc.subject.MESHLymphoproliferative Disorders/pathology*-
dc.subject.MESHProto-Oncogene Proteins c-bcl-6-
dc.subject.MESHSarcoma, Kaposi/metabolism-
dc.subject.MESHSarcoma, Kaposi/pathology-
dc.subject.MESHTubulin/metabolism*-
dc.titleClass III beta-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorWook Youn Kim-
dc.contributor.googleauthorHeounjeong Go-
dc.contributor.googleauthorJin Ho Paik-
dc.contributor.googleauthorJi Eun Kim-
dc.contributor.googleauthorYoung A. Kim-
dc.contributor.googleauthorJoo R. Huh-
dc.contributor.googleauthorYoon Kyung Jeon-
dc.contributor.googleauthorChul-Woo Kim-
dc.identifier.doi10.1097/PAS.0b013e3181d5d903-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02566-
dc.relation.journalcodeJ00120-
dc.identifier.pmid20220512-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000478-201005000-00006&LSLINK=80&D=ovft-
dc.subject.keywordclass III [beta]-tubulin-
dc.subject.keywordHodgkin lymphoma-
dc.subject.keywordnon-Hodgkin lymphoma-
dc.subject.keywordlymphoproliferative disorder-
dc.subject.keywordfollicular dendritic cell-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.citation.volume34-
dc.citation.number5-
dc.citation.startPage645-
dc.citation.endPage655-
dc.identifier.bibliographicCitationAmerican Journal of Surgical Pathology, Vol.34(5) : 645-655, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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