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Efficacy of Tandem High-Dose Chemotherapy and Autologous Stem Cell Rescue in Patients Over 1 Year of Age with Stage 4 Neuroblastoma: The Korean Society of Pediatric Hematology-Oncology Experience Over 6 Years (2000-2005).

DC FieldValueLanguage
dc.contributor.author원성철-
dc.contributor.author유철주-
dc.date.accessioned2015-04-23T17:45:04Z-
dc.date.available2015-04-23T17:45:04Z-
dc.date.issued2010-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103060-
dc.description.abstractThe efficacy of tandem high-dose chemotherapy and autologous stem cell rescue (HDCT/ASCR) was investigated in patients with high-risk neuroblastoma. Patients over 1 yr of age who were newly diagnosed with stage 4 neuroblastoma from January 2000 to December 2005 were enrolled in The Korean Society of Pediatric Hematology-Oncology registry. All patients who were assigned to receive HDCT/ASCR at diagnosis were retrospectively analyzed to investigate the efficacy of single or tandem HDCT/ASCR. Seventy and 71 patients were assigned to receive single or tandem HDCT/ASCR at diagnosis. Fifty-seven and 59 patients in the single or tandem HDCT group underwent single or tandem HDCT/ASCR as scheduled. Twenty-four and 38 patients in the single or tandem HDCT group remained event free with a median follow-up of 56 (24-88) months. When the survival rate was analyzed according to intent-to-treat at diagnosis, the probability of the 5-yr event-free survival+/-95% confidence intervals was higher in the tandem HDCT group than in the single HDCT group (51.2+/-12.4% vs. 31.3+/-11.5%, P=0.030). The results of the present study demonstrate that the tandem HDCT/ASCR strategy is significantly better than the single HDCT/ASCR strategy for improved survival in the treatment of high-risk neuroblastoma patients-
dc.description.statementOfResponsibilityopen-
dc.format.extent691~697-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCombined Modality Therapy/mortality-
dc.subject.MESHDrug Therapy/mortality*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHNeuroblastoma/mortality*-
dc.subject.MESHNeuroblastoma/therapy*-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Assessment/methods-
dc.subject.MESHRisk Factors-
dc.subject.MESHStem Cell Transplantation/mortality*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleEfficacy of Tandem High-Dose Chemotherapy and Autologous Stem Cell Rescue in Patients Over 1 Year of Age with Stage 4 Neuroblastoma: The Korean Society of Pediatric Hematology-Oncology Experience Over 6 Years (2000-2005).-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorKi Woong Sung-
dc.contributor.googleauthorHyo Seop Ahn-
dc.contributor.googleauthorBin Cho-
dc.contributor.googleauthorYong-Mook Choi-
dc.contributor.googleauthorNack Gyun Chung-
dc.contributor.googleauthorTai Ju Hwang-
dc.contributor.googleauthorHo Joon Im-
dc.contributor.googleauthorDae Chul Jeong-
dc.contributor.googleauthorHyoung Jin Kang-
dc.contributor.googleauthorHong Hoe Koo-
dc.contributor.googleauthorHoon Kook-
dc.contributor.googleauthorHack Ki Kim-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJong Jin Seo-
dc.contributor.googleauthorHee Young Shin-
dc.contributor.googleauthorKeon Hee Yoo-
dc.contributor.googleauthorSung Chul Won-
dc.contributor.googleauthorKun Soo Lee-
dc.identifier.doi10.3346/jkms.2010.25.5.691-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02434-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid20436703-
dc.subject.keywordNeuroblastoma-
dc.subject.keywordHigh-dose Chemotherapy-
dc.subject.keywordTransplantation-
dc.subject.keywordAutologous-
dc.contributor.alternativeNameWon, Sung Chul-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorWon, Sung Chul-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.citation.volume25-
dc.citation.number5-
dc.citation.startPage691-
dc.citation.endPage697-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(5) : 691-697, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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