Cited 6 times in
Effects of Cyclosporin A Therapy Combined with Steroids and Angiotensin Converting Enzyme Inhibitors on Childhood IgA Nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지홍 | - |
dc.contributor.author | 신재일 | - |
dc.contributor.author | 이재승 | - |
dc.contributor.author | 정현주 | - |
dc.date.accessioned | 2015-04-23T17:44:48Z | - |
dc.date.available | 2015-04-23T17:44:48Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103051 | - |
dc.description.abstract | To evaluate the effects of cyclosporin A (CyA) on clinical outcome and pathologic changes in children with IgA nephropathy (IgAN), we retrospectively evaluated 14 children (mean age 8.9+/-2.9 yr; eight males, six females) who were treated with CyA and steroids. The starting dose of CyA was 5 mg/kg per day, and the drug level was maintained at 100-200 ng/mL. The mean CyA level was 183.8+/-48.3 ng/mL (range 120.7-276.0 ng/mL) and the mean duration of CyA therapy was 10.9+/-1.9 months (range 8-12 months). After CyA therapy the mean 24 hr urinary protein excretion declined from 107.1+/-35.1 mg/m2/hr to 7.4+/-2.4 mg/m2/hr (P<0.001) and serum albumin increased from 3.3+/-0.6 g/dL to 4.3+/-0.3 g/dL (P<0.001). At a follow-up biopsy the histological grade of IgAN was improved in seven (50%) of the 14 patients, remained the same in three (21%), and was aggravated in four (29%). Serum creatinine, creatinine clearance, and blood pressure did not differ before and after CyA therapy. Two patients (14%) showed CyA-induced nephrotoxicity at the second biopsy. Our findings indicate that CyA therapy may be effective in reducing proteinuria and regressing renal pathology in a subset of children with IgAN. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angiotensin-ConvertingEnzymeInhibitors/administration & dosage* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Cyclosporine/administration & dosage* | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerulonephritis,IGA/diagnosis* | - |
dc.subject.MESH | Glomerulonephritis,IGA/drugtherapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/administration & dosage | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Steroids/administration & dosage* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of Cyclosporin A Therapy Combined with Steroids and Angiotensin Converting Enzyme Inhibitors on Childhood IgA Nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Pyung Kil Kim | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.contributor.googleauthor | Ji Hong Kim | - |
dc.identifier.doi | 10.3346/jkms.2010.25.5.723 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01003 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A03076 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03771 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 20436708 | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Cyclosporine | - |
dc.subject.keyword | Glomerulonephritis,IGA | - |
dc.subject.keyword | Heavy Proteinuria | - |
dc.contributor.alternativeName | Kim, Ji Hong | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.alternativeName | Lee, Jae Seung | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hong | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seung | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon Joo | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 723 | - |
dc.citation.endPage | 727 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(5) : 723-727, 2010 | - |
dc.identifier.rimsid | 35649 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.