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Effect of {beta}4 integrin knockdown by RNA interference in anaplastic thyroid carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노태웅 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2015-04-23T17:44:33Z | - |
dc.date.available | 2015-04-23T17:44:33Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103043 | - |
dc.description.abstract | BACKGROUND: Integrin α6β4 is a known tumor antigen; however, its function in different subtypes of thyroid cancer is not known. This study reports that α6β4 expression is selectively up-regulated in anaplastic thyroid cancer (ATC) cells, the most malignant subtype of human thyroid cancer. MATERIALS AND METHODS: To assess the contribution of α6β4 in ATC progression, cell proliferation, motility and soft agar assay were performed in vitro and a xenograft tumor growth assay was performed in vivo. RESULTS: Knockdown of β4 integrin subunit expression by shRNA in ATC cells reduced the proliferation, migration, and anchorage-independent growth of ATC cells in vitro and xenograft tumor growth in vivo. CONCLUSION: These data suggest that integrin α6β4 contributes to the development of aggressive forms of thyroid cancer with poor prognostic potential, such as ATC, and thus may be a novel therapeutic target for the treatment for this subtype of thyroid cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4485~4492 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Breast Neoplasms/prevention & control | - |
dc.subject.MESH | Carcinoma/genetics* | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Cell Adhesion | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Movement* | - |
dc.subject.MESH | Cell Proliferation* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Integrinalpha6beta4/genetics* | - |
dc.subject.MESH | Integrinalpha6beta4/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | RNAInterference* | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Small Interfering/genetics* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | ThyroidNeoplasms/genetics* | - |
dc.subject.MESH | ThyroidNeoplasms/pathology | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | Effect of {beta}4 integrin knockdown by RNA interference in anaplastic thyroid carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | TAE WOONG NOH | - |
dc.contributor.googleauthor | YOUNG HWA SOUNG | - |
dc.contributor.googleauthor | HONG IM KIM | - |
dc.contributor.googleauthor | HYEA JIN GIL | - |
dc.contributor.googleauthor | JEONG MO KIM | - |
dc.contributor.googleauthor | EUN JIG LEE | - |
dc.contributor.googleauthor | JUN CHUNG | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A01298 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 21115897 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/30/11/4485.abstract | - |
dc.subject.keyword | Integrin α6β4 | - |
dc.subject.keyword | thyroid cancer | - |
dc.subject.keyword | cell motility | - |
dc.subject.keyword | invasion | - |
dc.subject.keyword | anaplastic thyroid carcinoma | - |
dc.contributor.alternativeName | Noh, Tae Woong | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Noh, Tae Woong | - |
dc.citation.volume | 30 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 4485 | - |
dc.citation.endPage | 4492 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.30(11) : 4485-4492, 2010 | - |
dc.identifier.rimsid | 35644 | - |
dc.type.rims | ART | - |
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