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메밀 알레르기 진단에 있어서 16-kD 및 19-kD 재조합 알레르겐 특이 IgE 측정의 유용성
DC Field | Value | Language |
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dc.contributor.author | 이재현 | - |
dc.contributor.author | 홍천수 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 신유섭 | - |
dc.contributor.author | 이용원 | - |
dc.date.accessioned | 2015-04-23T17:42:57Z | - |
dc.date.available | 2015-04-23T17:42:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1226-8739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102991 | - |
dc.description.abstract | BACKGROUND: Buckwheat (BW, Fagopyrum esculentum)-specific IgE (sIgE) measurement is crucial to diagnose BW allergy. However, clinical application is difficult due to a high false-positive rate. Previously we identified 16-kD 2S storage albumin and 19-kD vicilin-like protein as BW major allergens. OBJECTIVE: To investigate clinical usefulness of sIgE measurements against recombinant 16- and 19-kD BW allergens compared to the skin prick test and measurement of specific IgE against whole buckwheat (WBW) extract. METHOD: Eleven BW allergic patients, 11 asymptomatic sensitizers to BW and 16 non-atopic subjects were enrolled. We performed the skin prick test, sIgE measurement against recombinant 16- and 19-kD BW allergens and WBW extract using a CAP system. RESULT: In BW allergic patients, sIgE against WBW extract, r16- and r19-kD BW allergens were detected in 10, 5 and 9 patients, respectively. In asymptomatic sensitizers, sIgE against WBW extract, r16- and r19-kD BW allergens were detected in 9, 1 and 2 patients respectively. In ROC analysis, the AUC value of sIgE level was higher in r19-kD allergen than in r16-kD or WBW extract. CONCLUSION: We suggest that CAP sIgE against r19-kD and r16-kD BW allergens can be a diagnostic marker to discriminate BW allergic patients from asymptomatic sensitizers in a clinical setting | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 209~215 | - |
dc.relation.isPartOf | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 메밀 알레르기 진단에 있어서 16-kD 및 19-kD 재조합 알레르겐 특이 IgE 측정의 유용성 | - |
dc.title.alternative | Measurement Specific IgE against Recombinant 16-kD and 19-kD Buckwheat Allergens for the Diagnosis of Buckwheat Allergy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 이재현 | - |
dc.contributor.googleauthor | 이용원 | - |
dc.contributor.googleauthor | 신유섭 | - |
dc.contributor.googleauthor | 박해심 | - |
dc.contributor.googleauthor | 홍천수 | - |
dc.contributor.googleauthor | 박중원 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A02981 | - |
dc.contributor.localId | A02130 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J01251 | - |
dc.subject.keyword | Buckwheat | - |
dc.subject.keyword | Allergy | - |
dc.subject.keyword | Recombinant | - |
dc.subject.keyword | Allergen | - |
dc.subject.keyword | Specific IgE measurement | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Shin, Yoo Seob | - |
dc.contributor.alternativeName | Lee, Yong Won | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Lee, Yong Won | - |
dc.contributor.affiliatedAuthor | Shin, Yoo Seob | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 209 | - |
dc.citation.endPage | 215 | - |
dc.identifier.bibliographicCitation | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.30(3) : 209-215, 2010 | - |
dc.identifier.rimsid | 35146 | - |
dc.type.rims | ART | - |
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